Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ACUTE MYELOID LEUKEMIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ACUTE MYELOID LEUKEMIA |
Knowledge base pages for this entity
graph TD
ACUTE_MYELOID_LEUKEMIA["ACUTE MYELOID LEUKEMIA"]
NPM1_Mutations["NPM1 Mutations"] -.biomarker for.-> ACUTE_MYELOID_LEUKEMIA
TP53["TP53"] -->|"risk_factor_for"| ACUTE_MYELOID_LEUKEMIA
PI3K_Akt_mTOR_Pathway["PI3K-Akt-mTOR Pathway"] -->|"involved_in"| ACUTE_MYELOID_LEUKEMIA
NPM1["NPM1"] -->|"causes"| ACUTE_MYELOID_LEUKEMIA
venetoclax["venetoclax"] -->|"treats"| ACUTE_MYELOID_LEUKEMIA
BCL2["BCL2"] -->|"target for"| ACUTE_MYELOID_LEUKEMIA
FLAG_IDA_chemotherapy["FLAG-IDA chemotherapy"] -->|"treats"| ACUTE_MYELOID_LEUKEMIA| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| NPM1 | associated_with | gene | 0.95 |
| NPM1 Mutations | biomarker_for | biomarker | 0.95 |
| TP53 | risk_factor_for | gene | 0.95 |
| TP53-Y220C | associated_with | gene | 0.95 |
| PI3K-Akt-mTOR Pathway | involved_in | pathway | 0.95 |
| NPM1 | causes | gene | 0.95 |
| venetoclax | treats | drug | 0.93 |
| BCL2 | therapeutic_target | protein | 0.92 |
| BCL2 | biomarker_for | protein | 0.92 |
| FLAG-IDA chemotherapy | treats | drug | 0.90 |
| BCL-2 | therapeutic_target | protein | 0.90 |
| CHIP | risk_factor_for | process | 0.90 |
| NPM1 | therapeutic_target | gene | 0.88 |
| Sy-1365 | treats | drug | 0.85 |
| NPM1 | drives | gene | 0.85 |
| BRAF | drives | gene | 0.85 |
| PI3K-Akt-mTOR pathway | causes | pathway | 0.80 |
| XPO1 | therapeutic_target | gene | 0.80 |
| MLL | therapeutic_target | gene | 0.80 |
| Cooperative Mutations | contributes_to | mechanism | 0.75 |
| HOX GENES | contributes_to | gene | 0.75 |
| NPM1-Targeted Therapy | targets | drug | 0.70 |
| MAPK inhibitor | treats | drug | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||