gene

XPO1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XPO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections
0Hypotheses
0Analyses
26Outgoing
25Incoming

Summary

XPO1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, implicated in. Associated with ALS, Als, Cancer. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolXPO1
Full NameExportin 1 (CRM1)
Chromosome2p15
Protein TypeReceptor
FunctionXPO1/CRM1 is a member of the karyopherin family
Primary Expressioncancer and neurodegenerative diseases
UniProt IDO14980
NCBI Gene ID7514
Ensembl IDENSG00000100401
GeneCardsXPO1
Human Protein AtlasXPO1
Associated Diseasesneurodegeneration
InteractionsNPM1, MYC, P53, CANCER, DNA, AND
KG Connections51 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: XPO1 — AlphaFold O14980 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

XPO1 Gene

gene · 776 words

NPM1 Gene

gene · 5653 words

Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases

mechanism · 2930 words

C9orf72-ALS Network

pathway · 2865 words

RAN Gene

gene · 2633 words

RNA Metabolism Dysfunction in Corticobasal Syndrome

mechanism · 1903 words

Pathway Diagram

graph TD
    XPO1["<b>XPO1</b>"]
    Leukemia{"Leukemia"}
    XPO1 -->|"expressed in"| Leukemia
    Ms{"Ms"}
    XPO1 -->|"expressed in"| Ms
    Als{"Als"}
    XPO1 -->|"expressed in"| Als
    ALS{"ALS"}
    XPO1 -->|"expressed in"| ALS
    NPM1["NPM1"]
    XPO1 -->|"inhibits"| NPM1
    GENES["GENES"]
    XPO1 -->|"expressed in"| GENES
    neurodegeneration["neurodegeneration"]
    XPO1 -->|"implicated in"| neurodegeneration
    NPM1 -->|"inhibits"| XPO1
    GENES -->|"expressed in"| XPO1
    AND["AND"]
    AND -->|"inhibits"| XPO1
    style XPO1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

TargetRelationTypeStr
ds-83b31ef18d49provides_data_fordataset1.00
TP53reducesprotein0.85
Acute Myeloid Leukemiatherapeutic_targetdisease0.80
NPM1-mutated Acute Myeloid Leukemiatherapeutic_targetdisease0.75
Leukemiaexpressed_indisease0.65

Incoming (25)

SourceRelationTypeStr
ds-83b31ef18d49data_indataset1.00
NPM1inhibitsgene0.60
CDK4inhibitsgene0.60
RB1inhibitsgene0.60
UBIQUITINinhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found