gene

NPM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

315Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Nucleophosmin - a multifunctional nucleolar phosphoprotein involved in ribosome biogenesis, DNA repair, p53 regulation, and nucleolar stress response in neurodegeneration

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🧬 Gene Info

Gene Symbol	NPM1
Aliases	Nucleophosmin
Chromosome	5q35.1
Protein Type	Chaperone
Target Class	Chaperone
Function	Small molecule modulators of nucleolar function and protein interactions
Mechanism of Action	Small molecule modulators of nucleolar function and protein interactions
Druggability	Low (0.30)
Clinical Stage	Phase III
Molecular Weight	37 kDa
Amino Acids	294 aa
Exons	12
Pathways	Apoptosis
UniProt ID	A0A7I2V5J8
Ensembl ID	ENSG00000126016
GeneCards	NPM1
Human Protein Atlas	NPM1
Associated Diseases	ALS, Acute Myeloid Leukemia, Cancer, Carcinoma, Cardiac
Known Drugs/Compounds	NSC348884
Interactions	NLRC5, CD8, IRF1, CIITA, G3BP1, XPO1
SciDEX Target	View Target Profile (10 clinical trials)
SciDEX Hypotheses	Nucleolar Stress Response Normalization
KG Connections	315 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NPM1 — AlphaFold A0A7I2V5J8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NPM1["NPM1"]
    NPM1 -->|"binds"| DNA["DNA"]
    NPM1 -.biomarker for.-> Leukemia["Leukemia"]
    NPM1 -.biomarker for.-> Ms["Ms"]
    NPM1 -->|"expressed in"| Als["Als"]
    NPM1 -->|"target for"| Cancer["Cancer"]
    NPM1 -->|"activates"| Tumor["Tumor"]
    h_ecacd219["h-ecacd219"] -->|"target for"| NPM1
    XPO1["XPO1"] -->|"inhibits"| NPM1
    GENES["GENES"] -->|"expressed in"| NPM1
    NLRC5["NLRC5"] -->|"activates"| NPM1
    IRF1["IRF1"] -->|"activates"| NPM1
    CIITA["CIITA"] -->|"activates"| NPM1
    DNA -->|"activates"| NPM1
    CD8["CD8"] -->|"activates"| NPM1
    NOTCH2NLC["NOTCH2NLC"] -->|"activates"| NPM1

Outgoing (243)

Target	Relation	Type	Str
Antigen Presentation	inhibits	process	0.95
Immune Evasion	associated_with	process	0.95
Acute Myeloid Leukemia	associated_with	disease	0.95
Immune Evasion	promotes	process	0.95
Tumor Progression	promotes	process	0.95
Acute Myeloid Leukemia	causes	disease	0.95
Tumor Progression	associated_with	process	0.90
AML Development	involved_in	process	0.90
AML Progression	involved_in	process	0.90
IRF1	associated_with	protein	0.90
Cd8+ T Cell Infiltration	inhibits	process	0.90
Cd8+ T Cell Activation	inhibits	process	0.90
Cytoplasm	transports	cell_type	0.90
Nucleus	transports	cell_type	0.90
cytoplasmic delocalization	causes	process	0.90
neuronal viability	regulates	phenotype	0.90
Acute Myeloid Leukemia	therapeutic_target	disease	0.88
Myeloid cell	expressed_in	cell_type	0.88
IRF1	interacts_with	protein	0.85
Survival Rate	correlates_with	phenotype	0.85
Tumor Microenvironment Reprogramming	regulates	process	0.85
Nucleophosmin Function	mediates	process	0.85
MHC-II	downregulates	protein	0.85
Immunosuppressive Cell Infiltration	promotes	process	0.85
Cd8+ T Cell Infiltration	suppresses	process	0.85
Cd8+ T Cell Activation	suppresses	process	0.85
Acute Myeloid Leukemia	drives	disease	0.85
AML progression	contributes_to	process	0.85
nucleolus	expressed_in	cell_type	0.85
ribosome biogenesis	regulates	process	0.85
cell proliferation	regulates	process	0.85
MHC-I	downregulates	protein	0.85
Leukemic cell development	involved_in	process	0.82
Tumor Antigen Presentation	inhibits	biological_process	0.80
Cell Nuclear Function	involved_in	process	0.80
Tumor Microenvironment Reprogramming	modulates	process	0.80
Preleukemic Clonal Hematopoiesis	associated_with	process	0.80
Measurable Residual Disease	associated_with	biomarker	0.80
AML prognosis	modulates	phenotype	0.80
Treatment response in AML	associated_with	phenotype	0.80
Measurable Residual Disease	biomarker_for	phenotype	0.80
preleukemic clonal hematopoiesis	involved_in	process	0.80
OTHER MUTATIONS	interacts_with	gene	0.80
genomic stability	regulates	process	0.80
embryonic development	associated_with	process	0.80
neurodegeneration	regulates	process	0.80
Cancer	biomarker_for	disease	0.80
neurodegenerative diseases	therapeutic_target	disease	0.80
nucleolar_function	regulates	pathway	0.80
Nucleolar function	regulates	process	0.78

Incoming (72)

Source	Relation	Type	Str
h-ecacd219	targets_gene	hypothesis	0.90
h-ecacd219	targets	hypothesis	0.80
XPO1	inhibits	gene	0.60
NLRC5	activates	gene	0.60
IRF1	activates	gene	0.60
CIITA	activates	gene	0.60
CD8	activates	gene	0.60
NOTCH2NLC	activates	gene	0.60
G3BP1	activates	gene	0.60
ENO1	associated_with	gene	0.60
MYC	associated_with	gene	0.60
CHOP	associated_with	gene	0.60
KMT2A	inhibits	gene	0.60
IRF1	interacts_with	entity	0.60
ARHGEF2	associated_with	entity	0.60
LMNA	associated_with	entity	0.60
PRDX1	interacts_with	gene	0.60
ARHGEF2	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
KDM5B	activates	gene	0.60
HNRNPA1	interacts_with	gene	0.60
angiogenesis	activates	process	0.60
MLL	inhibits	gene	0.60
ARID1A	activates	gene	0.60
ARID1A	expressed_in	gene	0.60
CR1	associated_with	gene	0.60
CR1	activates	gene	0.60
GENES	expressed_in	gene	0.60
DNA	activates	gene	0.60
GENES	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
GENE MUTATIONS	associated_with	gene	0.60
CANCER	causes	gene	0.60
NEUROTOXICITY	activates	gene	0.60
CANCER	associated_with	entity	0.60
AND	activates	gene	0.60
AND	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
RNA	regulates	gene	0.60
AND	interacts_with	gene	0.60
IRF2BP2	interacts_with	gene	0.60
AND	inhibits	gene	0.60
AND	causes	gene	0.60
MHC-I	activates	gene	0.60
RAS	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
DEMENTIA	interacts_with	gene	0.60
ALS	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Nucleolar Stress Response Normalization	0.378	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (1)

Scientific analyses that reference this entity

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.490

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
NPM1 inhibits tumoral antigen presentation to promote immune evasion and tumor p [PMID:39402629]	Wang X, Chai Y, Quan Y, Wang J, Song J,	J Hematol Oncol	2024	1
Significance of NPM1 Gene Mutations in AML. [PMID:34576201]	Hindley A, Catherwood MA, McMullin MF, M	Int J Mol Sci	2021	1
NPM1-mutated acute myeloid leukemia: from bench to bedside. [PMID:32609823]	Falini B, Brunetti L, Sportoletti P, Mar	Blood	2020	1
Insights into the regulation of neuronal viability by nucleophosmin/B23. [PMID:25908633]	Pfister JA, D'Mello SR	Exp Biol Med (Maywood)	2015	1
Functions of the histone chaperone nucleolin in diseases. [PMID:17484127]	Storck S, Shukla M, Dimitrov S, Bouvet P	Subcell Biochem	2007	1
Long-term outcomes in FLT3-mutated acute myeloid leukemia after frontline hypome [PMID:41035402]	Short NJ, Loghavi S, Yilmaz M, Karrar O,	Haematologica	2026	0
A Unified Model: Chromatin-Bound Multicomponent Condensates. [PMID:41481253]	Lau BK, Haarer EL, Ahn JH, Wang GG	Cancer Res	2026	0
Discovery and optimization of Menin-MLL inhibitors targeting acute myeloid leuke [PMID:41666760]	Xiao Q, Wang Y, Shen Z, Mo J, Li C et al	Eur J Med Chem	2026	0
Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to [PMID:41923577]	Bruzzese A, Vigna E, Martino EA, Caserta	Eur J Haematol	2026	0
Response to Comment on: "Prognostic implications of myelodysplasia-related gene [PMID:41924903]	Chang YS, Hou HA	Haematologica	2026	0
Quizartinib and omacetaxine mepesuccinate combination therapy in FLT3-ITD AML: a [PMID:41942459]	Zheng LC, Wong KKW, Lam SSY, Leung GMK,	Nat Commun	2026	0
CPX-351 (Liposomal Cytarabine and Daunorubicin) versus venetoclax plus hypomethy [PMID:41942467]	Fathima S, Rokach L, Ghosoun N, Rezasolt	Blood Cancer J	2026	0
Fibrillarin: bridging ribosome biogenesis and apoptosis in cellular stress and d [PMID:41518572]	["Zhang Z", "Zhang M", "Cao Z", "Zhao H"	Apoptosis : an international j	2026	0
Probing condensate microenvironments with a micropeptide killswitch. [PMID:40468084]	Zhang Y, Stöppelkamp I, Fernandez-Pernas	Nature	2025	0
Functions of the native NPM1 protein and its leukemic mutant. [PMID:39690184]	Falini B, Sorcini D, Perriello VM, Sport	Leukemia	2025	0
Spatial resolution of cellular senescence dynamics in human colorectal liver met [PMID:37157887]	["Garbarino O", "Lambroia L", "Basso G",	Aging cell	2023	0
Doxorubicin induces an alarmin-like TLR4-dependent autocrine/paracrine action of [PMID:34134693]	["Beji S", "D'Agostino M", "Gambini E",	BMC biology	2021	0
The nucleolus functions as a phase-separated protein quality control compartment [PMID:31296649]	Frottin F, Schueder F, Tiwary S, Gupta R	Science (New York, N.Y.)	2019	0
Small nucleoli are a cellular hallmark of longevity. [PMID:28853436]	["Tiku V", "Jain C", "Raz Y", "Nakamura	Nature communications	2017	0
Repression of rRNA transcription by PARIS contributes to Parkinson's disease. [PMID:25315684]	["Kang H", "Shin J"]	Neurobiology of disease	2015	0

NPM1

Understanding Entity Pages

Summary

Wiki Pages (21)

NPM1 Gene

ntrk1

DNA Damage Repair Therapy for Neurodegeneration

Dipeptide Repeat Proteins (DPRs) in C9orf72-ALS/FTD

rps27

NONO Gene

Sirtuin Signaling in 4R-Tauopathies

KDM5B (Lysine Demethylase 5B)

DNA Methylation Biomarkers in Neurodegeneration

DNA Damage-Accumulating Neurons in Neurodegeneration

DNA Repair Therapy for Neurodegeneration

Class II Major Histocompatibility Complex Transactivator

DNA Damage Repair Deficiency Validation Study in Parkinson's Disease

IRF1 Gene - Interferon Regulatory Factor 1

XPO1 Gene

ARHGEF2 Gene

ALK Protein

DNA Damage and Repair in Neurons

RPL5 Gene

DNA Damage Repair Therapy - Biomarker Guided