concept

ALTERNATIVE SPLICING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALTERNATIVE SPLICING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

1Analyses

12Outgoing

8Incoming

0Experiments

2Debates

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💡 Concept Info

Name	ALTERNATIVE SPLICING
Key Genes/Proteins	MAPT, TREM2
Related Diseases	AGING, ALS, ALZHEIMER, CANCER, CEREBROSPINAL FLUID

Pathway Diagram

graph TD
    ALTERNATIVE_SPLICING[ALTERNATIVE SPLICING]
    ALTERNATIVE_SPLICING -->|regulates| TARDBP[TARDBP]
    ALTERNATIVE_SPLICING -->|modulates| TGM2[TGM2]
    ALTERNATIVE_SPLICING -->|modulates| Gene_Function[Gene Function]
    ALTERNATIVE_SPLICING -->|contributes to| Proteomic_Complexity[Proteomic Complexity]
    ALTERNATIVE_SPLICING -->|activates| AGING[AGING]
    ALTERNATIVE_SPLICING -->|regulates| CANCER[CANCER]
    ALTERNATIVE_SPLICING -->|expressed in| CEREBROSPINAL_FLUID[CEREBROSPINAL FLUID]
    ALTERNATIVE_SPLICING -->|expressed in| ALS[ALS]
    ALTERNATIVE_SPLICING -->|implicated in| ALZHEIMER[ALZHEIMER]
    TDP_43[TDP-43] -->|regulates| ALTERNATIVE_SPLICING
    TDP43_Q331K[TDP43 Q331K] -->|modulates| ALTERNATIVE_SPLICING
    C9ORF72[C9ORF72] -->|modulates| ALTERNATIVE_SPLICING
    METTL3[METTL3] -->|regulates| ALTERNATIVE_SPLICING
    TREM2[TREM2] -->|produces| ALTERNATIVE_SPLICING
    SRPK1[SRPK1] -->|regulates| ALTERNATIVE_SPLICING

Outgoing (12)

Target	Relation	Type	Str
TARDBP	regulates	gene	0.95
TGM2	regulates	gene	0.90
TGM2	modulates	protein	0.90
TGM2 C-Terminal Truncation	associated_with	phenotype	0.90
Gene Function	modulates	process	0.85
Proteomic Complexity	contributes_to	phenotype	0.85
AGING	activates	phenotype	0.65
CANCER	regulates	disease	0.65
ALZHEIMER	implicated_in	disease	0.55
NEURON	expressed_in	cell_type	0.55
CEREBROSPINAL FLUID	expressed_in	phenotype	0.55
ALS	expressed_in	disease	0.55

Incoming (8)

Source	Relation	Type	Str
TDP-43	regulates	protein	0.95
TGM2	associated_with	gene	0.95
C9ORF72	modulates	gene	0.90
TDP43 Q331K	modulates	protein	0.90
METTL3	regulates	protein	0.85
MAPT	regulates	gene	0.70
TREM2	produces	gene	0.65
SRPK1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Cas13 gRNA Design for Silencing MAPT (Tau) Transcripts in Alzheimer's Disease

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Can optimized Cas13 guide RNAs selectively silence pathogenic MAPT splice varian

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Is Cas13-based 4R-tau silencing feasible given collateral cleavage risks in post

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning ALTERNATIVE SPLICING in their description or question text

No additional research found