protein

ambra1-protein

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ambra1-protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	AMBRA1
Aliases	ambra1-protein
Function	AMBRA1 (Activating Molecule in Beclin 1-Regulated Autophagy) is a critical positive regulator of autophagy that acts upstream of the Beclin 1 complex
Pathways	PI3K, mTOR
GeneCards	AMBRA1
Human Protein Atlas	AMBRA1
Associated Diseases	Cancer, Neurodegeneration, Cardiovascular, Ischemia, Parkinson, Ms
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

ambra1-protein

protein · 1603 words

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Pathway Diagram

graph TD
    AMBRA1["AMBRA1"]
    DNA["DNA"]
    AMBRA1 -->|"interacts_with"| DNA
    STEM_CELLS["STEM CELLS"]
    AMBRA1 -->|"interacts_with"| STEM_CELLS
    MITOPHAGY["MITOPHAGY"]
    AMBRA1 -->|"regulates"| MITOPHAGY
    CD4["CD4"]
    AMBRA1 -->|"associated_with"| CD4
    MTOR["MTOR"]
    AMBRA1 -->|"activates"| MTOR
    NIX["NIX"]
    AMBRA1 -->|"activates"| NIX
    Apoptosis["Apoptosis"]
    AMBRA1 -->|"involved_in"| Apoptosis
    peroxisome["peroxisome"]
    AMBRA1 -->|"regulates"| peroxisome
    NLR["NLR"]
    AMBRA1 -->|"inhibits"| NLR
    MDM2["MDM2"]
    AMBRA1 -->|"activates"| MDM2
    Cancer["Cancer"]
    AMBRA1 -->|"regulates"| Cancer
    WDR45["WDR45"]
    AMBRA1 -->|"associated_with"| WDR45
    style AMBRA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style DNA fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style STEM_CELLS fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MITOPHAGY fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CD4 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MTOR fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NIX fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Apoptosis fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style peroxisome fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NLR fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MDM2 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style WDR45 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ambra1-protein in their description or question text

No additional research found