Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ischemia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Ischemia is a disease characterized by neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 1302 entities in the SciDEX knowledge graph.
| Associated Genes | ULK1, BCL2, RAB9A, BCL2L1, GLA, GABARAP, PSEN2, CTSD |
| KG Connections | 1840 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
ACTB["ACTB"] -->|"regulates"| Ischemia["Ischemia"]
PPARA["PPARA"] -->|"regulates"| Ischemia["Ischemia"]
CAT["CAT"] -->|"regulates"| Ischemia["Ischemia"]
SQSTM1["SQSTM1"] -->|"regulates"| Ischemia["Ischemia"]
style Ischemia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | regulates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Oxidative Stress | inhibits | pathway | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | regulates | pathway | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Cardiac | activates | disease | 1.00 |
| Cardiac | therapeutic_target | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Angiogenesis | activates | pathway | 1.00 |
| Inflammation | implicated_in | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Apoptosis | regulates | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Alzheimer | associated_with | disease | 0.95 |
| Autophagy | upregulates | process | 0.95 |
| Inflammation | treats | disease | 0.95 |
| Inflammation | inhibits | disease | 0.95 |
| AUTOPHAGY | upregulates | process | 0.95 |
| Lipid Droplet Accumulation | promotes | phenotype | 0.90 |
| ALOX12 | upregulates | gene | 0.90 |
| Ferroptosis | inhibits | pathway | 0.90 |
| Autophagy | therapeutic_target | pathway | 0.90 |
| Ferroptosis | therapeutic_target | pathway | 0.90 |
| Immune Response | activates | pathway | 0.90 |
| Neurodegeneration | associated_with | disease | 0.85 |
| Inflammation | associated_with | disease | 0.85 |
| Apoptosis | causes | pathway | 0.85 |
| Pi3K/Akt | activates | pathway | 0.85 |
| Neurodegeneration | regulates | disease | 0.85 |
| Myocardial Infarction | activates | disease | 0.85 |
| Cardiac | implicated_in | disease | 0.85 |
| Myocardial Infarction | therapeutic_target | disease | 0.85 |
| TNF-α | upregulates | protein | 0.85 |
| IL-6 | upregulates | protein | 0.85 |
| IL-1β | upregulates | protein | 0.85 |
| NLRP3 | activates | protein | 0.80 |
| NEURODEGENERATION | contributes_to | process | 0.80 |
| Autophagy | associated_with | pathway | 0.80 |
| Mitochondrial Function | activates | pathway | 0.80 |
| Apoptosis | associated_with | pathway | 0.80 |
| Oxidative Stress | associated_with | pathway | 0.80 |
| Oxidative Stress | treats | pathway | 0.80 |
| Stem Cell | activates | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GENES | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| APOPTOSIS | regulates | gene | 1.00 |
| AUTOPHAGY | regulates | gene | 1.00 |
| MITOPHAGY | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| OXIDATIVE STRESS | inhibits | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| OXIDATIVE STRESS | regulates | gene | 1.00 |
| VEGF | activates | gene | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| MICROGLIA | regulates | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| STROKE | activates | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| STROKE | associated_with | gene | 1.00 |
| STROKE | inhibits | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| STROKE | therapeutic_target | gene | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| Stroke | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Stroke | inhibits | disease | 1.00 |
| MITOCHONDRIA | therapeutic_target | gene | 1.00 |
| Stroke | activates | disease | 1.00 |
| NRF2 | activates | gene | 0.95 |
| BNIP3 | regulates | gene | 0.95 |
| Stroke | associated_with | disease | 0.95 |
| PI3K | activates | gene | 0.95 |
| BAX | activates | gene | 0.95 |
| TNF | activates | gene | 0.95 |
| BRAIN INJURY | associated_with | gene | 0.95 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.95 |
| FERROPTOSIS | inhibits | gene | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.548
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||