Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about cell_type: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Transcriptome | correlates_with | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPR37 | expressed_in | protein | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-S | 0.576 | neurodegeneration | What are the cell-type-specific transcri |
| Cell-Type Specific TREM2 Upregulation in DAM Microglia | 0.519 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
| Cell-Type Specific TFEB Modulation | 0.482 | neurodegeneration | Does TFEB dysfunction cause neurodegener |
| Cell-Type Specific Metabolic Reprogramming | 0.471 | neurodegeneration | Cell type vulnerability in Alzheimers Di |
| Cross-Cell Type Synaptic Rescue via Tripartite Synapse Resto | 0.454 | neurodegeneration | Cell type vulnerability in Alzheimer's D |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neuropharmacology | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Protein [PMID:41900026] | Jamerlan A, Hulme J | Molecules (Basel, Switzerland) | 2026 | 0 |
| Mammalian lipophagy: process and function. [PMID:41681129] | Zhao R, Dai E, Kang R, Liu J, Klionsky D | Autophagy | 2026 | 0 |
| Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lys [PMID:41272418] | Tang B, Xu X, Zhao W, Zhou Q, Du G et al | J Cereb Blood Flow Metab | 2026 | 0 |
| Endothelial Transcription Factor EB Protects Against Doxorubicin-Induced Endothe [PMID:41410033] | Du W, Ringer M, Desai D, Khandakar GI, T | Circulation | 2026 | 0 |
| Proteotoxic stress triggers TFEB- and TFE3-mediated autophagy and lysosomal biog [PMID:41450115] | Zhu Z, Yang J, Montefusco S, Xia S, Ou J | Autophagy | 2026 | 0 |
| Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing [PMID:41673711] | Kim Y, Ha TY, Kondaurova O, Lee MS, Chan | J Neuroinflammation | 2026 | 0 |
| TFE3-Rearranged and TFEB-Altered Renal Cell Carcinomas: Molecular Landscape and [PMID:41899560] | Portu M, Balsa M, Cotaina M, Anguera G, | Cancers (Basel) | 2026 | 0 |
| Transcription Factor EB Drives Thrombospondin-1 Expression to Dampen Focal-adhes [PMID:41935359] | Liu C, Zhang Q, Zhou D, Li B, Cheng J et | Curr Gene Ther | 2026 | 0 |
| Modulation of the AMPK/TFEB Axis by Ezetimibe Attenuates Neuroinflammatory, Oxid [PMID:41944914] | Aditi, Wani SN, Akanksha, Kumar A, Singh | Journal of neuroimmune pharmac | 2026 | 0 |
| TFEB has a protective effect in cisplatin induced AKI through regulating exosome [PMID:41946126] | Xu Z, Xiang H, Liu H, Zhang C, Zhang X e | Int Immunopharmacol | 2026 | 0 |
| Cabozantinib activates TFEB-mediated autophagy to exert anti-tumor effects in he [PMID:41951909] | Chen C, Hu Y, Zhang C, Zhou X | In Vitro Cell Dev Biol Anim | 2026 | 0 |
| NIBV Induces Incomplete Autophagy via AMPK-TFEB, Causing Kidney Injury in Chicks [PMID:41955488] | Huang C, Zeng Y, Chen Y, Li Z, Omar SM e | Adv Sci (Weinh) | 2026 | 0 |
| Lysosomal homeostasis at the crossroads of neurodegeneration. [PMID:41919495] | De Tito S, Tooze SA | The Journal of clinical invest | 2026 | 0 |
| Targeting microglial inflammation in Parkinson's disease: irisin activates PAFAH [PMID:41520051] | Cai L, Liu Y, Tang S, Deng S, Zhang L, W | Communications biology | 2026 | 0 |
| Organelle dysfunction and TNT-mediated aggregate spreading in neurodegeneration. [PMID:41543365] | Thomas V, Zurzolo C | Physiology (Bethesda, Md.) | 2026 | 0 |
| Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852] | ["Ramirez G", "Hernandez D", "Teal A", " | Research square | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven G, Gezegen H, Şahin E, Samancı B, | Acta neurologica Belgica | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759] | Ishizu H, Hasegawa T, Shimizu T, Yamamot | Bone | 2026 | 0 |