gene

GPR37

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPR37: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

343Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

GPR37 (Parmethin) is an orphan GPCR highly expressed in the CNS and substrates of parkin. It plays critical roles in Parkinson's disease pathogenesis through the PSAP-GPR37-IL-6 axis in oligodendrocytes, ER stress response, and protein quality control mechanisms.

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🧬 Gene Info

Gene Symbol	GPR37
Aliases	Parmethin
Chromosome	7q31.3
Protein Type	Gpcr
Target Class	Gpcr
Function	GPR37 agonists or modulators would activate the receptor to promote dopaminergic neuron survival and neuroprotection, counteracting the neurodegeneration characteristic of Parkinson's disease. Liga...
Mechanism of Action	GPR37 agonists or modulators would activate the receptor to promote dopaminergic neuron survival and neuroprotection, counteracting the neurodegeneration characteristic of Parkinson's disease. Ligands binding to GPR37 would enhance G-protein signaling cascades that support neuronal viability and function.
Primary Expression	the central nervous system
Druggability	Low (0.30)
Clinical Stage	Approved
Molecular Weight	52 kDa
Amino Acids	462 aa
Pathways	Apoptosis, Neuroinflammatory, Oxidative Stress
UniProt ID	O15354
Ensembl ID	ENSG00000170370
GeneCards	GPR37
Human Protein Atlas	GPR37
Associated Diseases	ALS, ALZHEIMER, Alzheimer's disease, Cancer, INFLAMMATION, Infection
Known Drugs/Compounds	Prosaposin, TX14(A)
Interactions	IL6, PSAP, SMAD4, CTSD, PD1, PI3K
SciDEX Target	View Target Profile (10 clinical trials)
SciDEX Hypotheses	Oligodendrocyte Protectin D1 Mimetic for Myelin Re
KG Connections	343 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GPR37 — AlphaFold O15354 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GPR37["GPR37"]
    GPR37 -->|"activates"| Als["Als"]
    GPR37 -->|"activates"| Ms["Ms"]
    GPR37 -->|"activates"| Inflammation["Inflammation"]
    GPR37 -.protects against.-> Neurodegeneration["Neurodegeneration"]
    GPR37 -->|"activates"| Neuroinflammation["Neuroinflammation"]
    GPR37 -->|"activates"| Parkinson["Parkinson"]
    GPR37 -->|"regulates"| Stroke["Stroke"]
    h_f71a9791["h-f71a9791"] -->|"target for"| GPR37
    PROSAPOSIN["PROSAPOSIN"] -->|"activates"| GPR37
    PSAP["PSAP"] -->|"activates"| GPR37
    BANG["BANG"] -->|"activates"| GPR37
    GALC["GALC"] -->|"activates"| GPR37
    RAC1["RAC1"] -->|"activates"| GPR37
    CANCER["CANCER"] -->|"activates"| GPR37
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| GPR37
    MICROGLIA["MICROGLIA"] -->|"expressed in"| GPR37

Outgoing (269)

Target	Relation	Type	Str
cell_type	expressed_in	entity	0.95
Microglia	associated_with	cell_type	0.90
oligodendrocytes	expressed_in	cell_type	0.88
IL6	upregulates	gene	0.85
pro-inflammatory cytokine production	regulates	process	0.85
anti-inflammatory cytokine production	regulates	process	0.85
PROINFLAMMATORY CYTOKINE	regulates	protein	0.80
ANTIINFLAMMATORY CYTOKINE	regulates	protein	0.80
Proinflammatory Cytokines	regulates	process	0.80
neuroinflammation	contributes_to	process	0.80
stroke	implicated_in	disease	0.80
demyelinating disorders	implicated_in	disease	0.80
antiinflammatory cytokines	regulates	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
NEUROLOGICAL DISEASES	implicated_in	disease	0.80
GPR37_receptor	encodes	protein	0.80
Inflammation	activates	disease	0.75
phagocytosis	activates	process	0.70
neuroinflammation	mediates	process	0.70
macrophages	expressed_in	cell_type	0.70
unfolded protein response	participates_in	pathway	0.70
oligodendrocytes	inhibits	cell_type	0.70
oligodendrocytes	protects_against	cell_type	0.70
neurons	implicated_in	cell_type	0.70
Als	activates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	inhibits	disease	0.65
Parkinson	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Stroke	regulates	disease	0.65
Ms	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	causes	disease	0.65
ALS	inhibits	disease	0.65
Pain	activates	disease	0.65
IL6	regulates	gene	0.64
IL6	activates	gene	0.64
OLIGODENDROCYTES	expressed_in	cell_type	0.64
PSAP	activates	gene	0.60

Incoming (74)

Source	Relation	Type	Str
PSAP	binds_to	protein	0.92
h-f71a9791	targets_gene	hypothesis	0.90
Zymosan Injection	upregulates	process	0.85
h-f71a9791	targets	hypothesis	0.80
PROSAPOSIN	binds_to	protein	0.80
BGLAP	binds	gene	0.75
PROSAPOSIN	activates	protein	0.72
PSAP	activates	protein	0.64
BANG	activates	gene	0.60
GALC	activates	gene	0.60
RAC1	activates	gene	0.60
cannabidiol	associated_with	compound	0.60
CANCER	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
MYELIN	inhibits	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
NEURON	activates	gene	0.60
STROKE	associated_with	gene	0.60
APOPTOSIS	regulates	gene	0.60
ASTROCYTES	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
STROKE	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
CYTOKINES	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
CYTOKINES	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
INFLAMMATION	causes	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
AND	activates	gene	0.60
CANCER	expressed_in	entity	0.60
IL-6	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
AND	regulates	gene	0.60
RNA	regulates	gene	0.60
CANCER	associated_with	gene	0.60
MYELIN	regulates	gene	0.60
C1Q	activates	gene	0.55
ENDOG	co_discussed	protein	0.50
PSAP	associated_with	gene	0.50
PHAGOCYTOSIS	regulates	gene	0.50
microglia	expressed_in	cell_type	0.50
Neuroinflammation	causes	process	0.50
Neurodegeneration	causes	disease	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution	0.447	neurodegeneration	Neuroinflammation resolution mechanisms

Mentioning Analyses (2)

Scientific analyses that reference this entity

How do oligodendrocytes initiate neuroinflammation in PD when microglia are trad

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Role and regulatory mechanism of GPR37 in neurological diseases. [PMID:40822851]	Liu S, Bai T, Liu X, Zhao W, Li X, Sui Y	Front Cell Neurosci	2025	1
Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's di [PMID:39913287]	Ma Q, Tian JL, Lou Y, Guo R, Ma XR, Wu J	Cell Rep	2025	1
Inflammation and Infection in Pain and the Role of GPR37. [PMID:36430912]	Zhang Q, Bang S, Chandra S, Ji RR	Int J Mol Sci	2022	1
Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 [PMID:34678058]	Qian Z, Li H, Yang H, Yang Q, Lu Z, Wang	Sci Adv	2021	1
GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. [PMID:30010619]	Bang S, Xie YK, Zhang ZJ, Wang Z, Xu ZZ,	J Clin Invest	2018	1
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
GPR37 processing in neurodegeneration: a potential marker for Parkinson's Diseas [PMID:39256360]	["Argerich J", "Garma L", "L\u00f3pez-Ca	NPJ Parkinson's disease	2024	0
Activation of GPR37 in macrophages confers protection against infection-induced [PMID:33731716]	Bang S, Donnelly CR, Luo X, Toro-Moreno	Nature communications	2021	0
Disparities in maternal health services in sub-Saharan Africa. [PMID:29572718]	["Woldegiorgis M", "Hiller J", "Mekonnen	International journal of publi	2018	0
Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycopr [PMID:28642167]	["Smith B", "Giddens M", "Neil J", "Owin	Neuroscience	2017	0
Research Designs for Intervention Research with Small Samples II: Stepped Wedge [PMID:26017633]	["Fok C", "Henry D", "Allen J"]	Prevention science : the offic	2015	0
Global genomic profiling reveals an extensive p53-regulated autophagy program co [PMID:23651856]	["Kenzelmann Broz D", "Spano Mello S", "	Genes & development	2013	0
Phylogenetic-based propagation of functional annotations within the Gene Ontolog [PMID:21873635]	["Gaudet P", "Livstone M", "Lewis S", "T	Briefings in bioinformatics	2011	0
Pael receptor induces death of dopaminergic neurons in the substantia nigra via [PMID:17116640]	["Kitao Y", "Imai Y", "Ozawa K", "Kataok	Human molecular genetics	2007	0
Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and [PMID:16539653]	["Kubota K", "Niinuma Y", "Kaneko M", "O	Journal of neurochemistry	2006	0
Pael receptor, endoplasmic reticulum stress, and Parkinson's disease. [PMID:14579121]	Takahashi R, Imai Y	Journal of neurology	2003	0
Neurodegeneration: how does parkin prevent Parkinson's disease? [PMID:12842030]	Cookson MR	Current biology : CB	2003	0

GPR37

Understanding Entity Pages

Summary

Wiki Pages (21)

GPR37 Gene

neuroinflammation

TGF-β Signaling in Parkinson's Disease

PTCH2 Gene

endoplasmic-reticulum-stress

Neuroinflammation Pathway

Neurons

PSAP-GPR37-IL-6 Axis in Parkinson's Disease

AP2A2 — Adaptor-Related Protein Complex 2 Subunit Alpha 2

G-Protein Coupled Receptor Signaling in Parkinson's Disease

Neuroinflammation in PD

Neurons in Dentatorubral-Pallidoluysian Atrophy

vps26

Specialized Pro-Resolving Mediators in Neurodegeneration

Neuroinflammation in Corticobasal Degeneration

PARK2/Parkin Ubiquitin Ligase Pathway in Parkinson's Disease

GPR37 Protein

Neuroinflammation in Corticobasal Syndrome

GPR37 Modulator Therapy for Parkinson's Disease

Phosphodiesterase Inhibitors for Parkinson's Disease

G Protein-Coupled Receptor 37 Like 1 Protein