Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CEREBRAL SMALL VESSEL DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CEREBRAL SMALL VESSEL DISEASE |
Knowledge base pages for this entity
graph TD
CEREBRAL_SMALL_VESSEL_DISEASE["CEREBRAL SMALL VESSEL DISEASE"]
CEREBRAL_SMALL_VESSEL_DISEASE -->|"causes"| Lacunar_Stroke["Lacunar Stroke"]
CEREBRAL_SMALL_VESSEL_DISEASE -->|"causes"| Intracerebral_Hemorrhage["Intracerebral Hemorrhage"]
CEREBRAL_SMALL_VESSEL_DISEASE -->|"causes"| Vascular_Cognitive_Impairment["Vascular Cognitive Impairment"]
CEREBRAL_SMALL_VESSEL_DISEASE -->|"causes"| Cognitive_Impairment["Cognitive Impairment"]
CEREBRAL_SMALL_VESSEL_DISEASE -->|"causes"| Depression["Depression"]
CEREBRAL_SMALL_VESSEL_DISEASE -->|"causes"| Apathy["Apathy"]
CEREBRAL_SMALL_VESSEL_DISEASE -->|"causes"| Gait_Disturbance["Gait Disturbance"]
Arteriolosclerosis["Arteriolosclerosis"] -->|"contributes to"| CEREBRAL_SMALL_VESSEL_DISEASE
Cerebral_Amyloid_Angiopathy["Cerebral Amyloid Angiopathy"] -->|"contributes to"| CEREBRAL_SMALL_VESSEL_DISEASE
White_Matter_Hyperintensities["White Matter Hyperintensities"] -.biomarker for.-> CEREBRAL_SMALL_VESSEL_DISEASE
Lacunar_Infarcts["Lacunar Infarcts"] -.biomarker for.-> CEREBRAL_SMALL_VESSEL_DISEASE
Ion_Channel_Dysfunction["Ion Channel Dysfunction"] -->|"causes"| CEREBRAL_SMALL_VESSEL_DISEASE
Inflammation["Inflammation"] -->|"involved_in"| CEREBRAL_SMALL_VESSEL_DISEASE| Target | Relation | Type | Str |
|---|---|---|---|
| Lacunar Stroke | causes | disease | 0.95 |
| Intracerebral Hemorrhage | causes | disease | 0.95 |
| Vascular Cognitive Impairment | causes | disease | 0.95 |
| vascular cognitive impairment and dementia | causes | disease | 0.90 |
| Parkinsonism | associated_with | phenotype | 0.85 |
| Cognitive Impairment | causes | phenotype | 0.85 |
| Apathy | causes | phenotype | 0.80 |
| Gait Disturbance | causes | phenotype | 0.80 |
| ischemic stroke | causes | disease | 0.80 |
| Depression | causes | phenotype | 0.80 |
| Depression | associated_with | phenotype | 0.80 |
| DEMENTIA | causes | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Arteriolosclerosis | contributes_to | disease | 0.90 |
| Cerebral Amyloid Angiopathy | contributes_to | disease | 0.90 |
| Lacunar Infarcts | biomarker_for | biomarker | 0.90 |
| HYPERTENSION | causes | disease | 0.90 |
| Ion Channel Dysfunction | causes | mechanism | 0.80 |
| Ion Channel Dysfunction | associated_with | mechanism | 0.80 |
| ion channel dysfunction | implicated_in | phenotype | 0.80 |
| Inflammation | involved_in | process | 0.80 |
| Endothelial Dysfunction | involved_in | process | 0.75 |
| Blood-Brain Barrier Integrity | involved_in | mechanism | 0.73 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||