Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ENDOTHELIAL DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ENDOTHELIAL DYSFUNCTION |
Knowledge base pages for this entity
graph TD
ENDOTHELIAL_DYSFUNCTION["ENDOTHELIAL DYSFUNCTION"]
ENDOTHELIAL_DYSFUNCTION -->|"contributes to"| Vascular_Brain_Injury["Vascular Brain Injury"]
ENDOTHELIAL_DYSFUNCTION -->|"contributes to"| Pulmonary_Vascular_Remodeling["Pulmonary Vascular Remodeling"]
ENDOTHELIAL_DYSFUNCTION -->|"contributes to"| Atherosclerosis["Atherosclerosis"]
ENDOTHELIAL_DYSFUNCTION -->|"causes"| Atherosclerotic_Cardiovascular["Atherosclerotic Cardiovascular Diseases"]
ENDOTHELIAL_DYSFUNCTION -->|"contributes to"| Cerebrovascular_Dysfunction["Cerebrovascular Dysfunction"]
Cigarette_Smoking["Cigarette Smoking"] -->|"causes"| ENDOTHELIAL_DYSFUNCTION
Oxidative_Stress["Oxidative Stress"] -->|"contributes to"| ENDOTHELIAL_DYSFUNCTION
Nitric_Oxide["Nitric Oxide"] -->|"inhibits"| ENDOTHELIAL_DYSFUNCTION
TFEB["TFEB"] -.protects against.-> ENDOTHELIAL_DYSFUNCTION
Ethanol["Ethanol"] -->|"causes"| ENDOTHELIAL_DYSFUNCTION
SODs["SODs"] -->|"inhibits"| ENDOTHELIAL_DYSFUNCTION
LDLR_Family["LDLR Family"] -->|"modulates"| ENDOTHELIAL_DYSFUNCTION| Target | Relation | Type | Str |
|---|---|---|---|
| Vascular Brain Injury | contributes_to | process | 0.85 |
| blood-brain barrier integrity | associated_with | process | 0.85 |
| Dementia | associated_with | disease | 0.85 |
| Pulmonary Vascular Remodeling | contributes_to | process | 0.80 |
| Atherosclerotic Cardiovascular Diseases | causes | disease | 0.80 |
| Cerebrovascular Dysfunction | contributes_to | phenotype | 0.80 |
| sex | associated_with | phenotype | 0.80 |
| Atherosclerosis | contributes_to | disease | 0.80 |
| Cerebral Small Vessel Disease | involved_in | disease | 0.75 |
| Acute Respiratory Distress Syndrome | contributes_to | disease | 0.75 |
| Multisystem Organ Failure | contributes_to | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Cigarette Smoking | causes | drug | 0.95 |
| Nitric Oxide | inhibits | compound | 0.90 |
| Oxidative Stress | contributes_to | process | 0.90 |
| oxidative stress | drives | process | 0.90 |
| Traumatic Brain Injury | causes | disease | 0.90 |
| TFEB | protects_against | protein | 0.88 |
| Ethanol | causes | compound | 0.85 |
| Nitric Oxide | protects_against | compound | 0.85 |
| Superoxide Anion | contributes_to | compound | 0.85 |
| Endothelin | contributes_to | protein | 0.85 |
| LRP1 | contributes_to | gene | 0.85 |
| lipid oxidation | drives | pathway | 0.85 |
| SODs | inhibits | protein | 0.80 |
| LDLR Family | modulates | protein | 0.80 |
| LDLR FAMILY RECEPTORS | associated_with | receptor | 0.80 |
| LDLR | contributes_to | gene | 0.80 |
| PPARG | protects_against | gene | 0.80 |
| NLRP3 | associated_with | protein | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||