concept

HYPERTENSION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HYPERTENSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1059Connections

0Hypotheses

0Analyses

44Outgoing

22Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HYPERTENSION
Key Genes/Proteins	SIRT1, SMAD2, AMPK, BACE1
Related Diseases	cerebral small vessel disease, NEUROPATHY, GLAUCOMA, DIABETES, OBESITY
Related Pathways	MAPK PATHWAY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HYPERTENSION["HYPERTENSION"]
    HYPERTENSION -->|"contributes to"| Oxidative_Stress["Oxidative Stress"]
    HYPERTENSION -->|"target for"| Pi3K["Pi3K"]
    HYPERTENSION -->|"activates"| Autophagy["Autophagy"]
    HYPERTENSION -->|"activates"| Apoptosis["Apoptosis"]
    HYPERTENSION -->|"target for"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    HYPERTENSION -->|"target for"| Epigenetic["Epigenetic"]
    HYPERTENSION -->|"target for"| Amyloid["Amyloid"]
    superoxide_anion["superoxide anion"] -->|"causes"| HYPERTENSION
    PIEZO1["PIEZO1"] -->|"activates"| HYPERTENSION
    KCNK2["KCNK2"] -->|"activates"| HYPERTENSION
    TRPC1["TRPC1"] -->|"activates"| HYPERTENSION
    TRPV4["TRPV4"] -->|"activates"| HYPERTENSION
    FSP1["FSP1"] -->|"activates"| HYPERTENSION
    TRPA1["TRPA1"] -->|"regulates"| HYPERTENSION
    G3BP1["G3BP1"] -->|"activates"| HYPERTENSION

Outgoing (385)

Target	Relation	Type	Str
cerebral small vessel disease	causes	disease	0.90
NEUROPATHY	interacts_with	disease	0.65
APIGENIN	treats	drug	0.65
GLAUCOMA	increases_risk	disease	0.65
OBESITY	interacts_with	disease	0.50
APIGENIN	associated_with	drug	0.50
SIRT1	associated_with	gene	0.50
SMAD2	associated_with	gene	0.50
AMPK	associated_with	gene	0.50
BACE1	associated_with	gene	0.50
MAPK PATHWAY	associated_with	pathway	0.45
NAC	associated_with	drug	0.45
OPTN	associated_with	gene	0.45
GFAP	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
P38	associated_with	gene	0.45
NEURODEGENERATION	implicated_in	process	0.35
NEUROINFLAMMATION	activates	process	0.35
P38	activates	gene	0.35
INSULIN RESISTANCE	interacts_with	process	0.35
LUNG CANCER	interacts_with	disease	0.35
INFLAMMATION	interacts_with	process	0.35
N-ACETYLCYSTEINE	activates	drug	0.35
NAFLD	interacts_with	disease	0.35
LIPID METABOLISM	regulates	process	0.30
HEART FAILURE	causes	disease	0.30
MICROGLIA	associated_with	cell_type	0.30
MICROGLIA	regulates	cell_type	0.30
ASTROCYTES	activates	cell_type	0.30
MICROGLIA	activates	cell_type	0.30
ISCHEMIA	activates	disease	0.30
STAT3	activates	gene	0.30
DEMENTIA	biomarker_for	disease	0.30
ALZHEIMER'S DISEASE	associated_with	disease	0.30
PARKINSON'S DISEASE	associated_with	disease	0.30
TNF	inhibits	gene	0.30
CYTOKINES	inhibits	protein	0.30
IL-6	inhibits	gene	0.30
DEMENTIA	regulates	disease	0.30
NRF2	activates	gene	0.30
STROKE	regulates	disease	0.30
DEMENTIA	implicated_in	disease	0.30
DEMENTIA	interacts_with	disease	0.30
STROKE	interacts_with	disease	0.30

Incoming (674)

Source	Relation	Type	Str
DIABETES	interacts_with	disease	0.65
ENDOTHELIAL CELLS	causes	cell_type	0.65
ENDOTHELIAL CELLS	implicated_in	cell_type	0.50
MICROGLIA	associated_with	cell_type	0.44
DEMENTIA	interacts_with	disease	0.44
AMYLOID	causes	protein	0.35
GFAP	interacts_with	gene	0.35
ENDOTHELIAL CELLS	associated_with	cell_type	0.35
BREAST CANCER	interacts_with	disease	0.35
HEPATOCELLULAR CARCINOMA	interacts_with	disease	0.35
CIRRHOSIS	interacts_with	disease	0.35
LIPID METABOLISM	associated_with	process	0.30
ATHEROSCLEROSIS	associated_with	disease	0.30
ISCHEMIA	regulates	disease	0.30
STAT3	causes	gene	0.30
EGFR	causes	gene	0.30
AGING	inhibits	process	0.30
CYTOKINES	inhibits	protein	0.30
SENESCENCE	implicated_in	process	0.30
ASTROCYTES	associated_with	cell_type	0.30
DEMENTIA	inhibits	disease	0.30
STROKE	inhibits	disease	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HYPERTENSION

Understanding Entity Pages

Wiki Pages (20)

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Clinical Management Guide for CBS/PSP

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

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Section 148: Advanced Nutritional Biochemistry in CBS/PSP

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rasagiline

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VEGF/Angiogenesis Pathway in Neurodegeneration

Coenzyme Q10 for Neurodegeneration

blood-brain-barrier

nf1-protein

Niemann-Pick Disease Type C (NPC)

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers