Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Gene Therapy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Gene Therapy |
| Key Genes/Proteins | APOE |
| Related Diseases | AADC Deficiency, Abnormal Gene Expression, ALS, ALZHEIMER'S DISEASE, Amyotrophic Lateral Sclerosis |
| Related Pathways | Delivery Challenges |
| Linked Hypotheses | 4 hypotheses |
Knowledge base pages for this entity
graph TD
Gene_Therapy["Gene Therapy"] -->|"modulates"| Abnormal_Gene_Expression["Abnormal Gene Expression"]
style Abnormal_Gene_Expression fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Gene_Therapy["Gene Therapy"] -->|"treats"| Spinal_Muscular_Atrophy["Spinal Muscular Atrophy"]
style Spinal_Muscular_Atrophy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Gene_Therapy["Gene Therapy"] -->|"treats"| Cerebral_Adrenoleukodystrophy["Cerebral Adrenoleukodystrophy"]
style Cerebral_Adrenoleukodystrophy fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Gene_Therapy["Gene Therapy"] -.->|"inhibits"| Motor_Neuron_Degeneration["Motor Neuron Degeneration"]
style Motor_Neuron_Degeneration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Gene_Therapy["Gene Therapy"] -->|"treats"| ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Gene_Therapy["Gene Therapy"] -->|"treats"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Gene_Therapy["Gene Therapy"] -->|"treats"| AADC_Deficiency["AADC Deficiency"]
style AADC_Deficiency fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
APOE["APOE"] -->|"targets"| Gene_Therapy["Gene Therapy"]
style APOE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Delivery_Strategies["Delivery Strategies"] -->|"mediates"| Gene_Therapy["Gene Therapy"]
style Delivery_Strategies fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Lipid_Nanoparticle_Systems["Lipid Nanoparticle Systems"] -->|"associated"| Gene_Therapy["Gene Therapy"]
style Lipid_Nanoparticle_Systems fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Routes_Of_Administration["Routes Of Administration"] -->|"involved in"| Gene_Therapy["Gene Therapy"]
style Routes_Of_Administration fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
style Gene_Therapy fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Abnormal Gene Expression | modulates | phenotype | 0.95 |
| Spinal Muscular Atrophy | treats | disease | 0.95 |
| Cerebral Adrenoleukodystrophy | treats | disease | 0.90 |
| ALZHEIMER'S DISEASE | treats | disease | 0.90 |
| PARKINSON'S DISEASE | treats | disease | 0.90 |
| Delivery Challenges | involved_in | mechanism | 0.85 |
| Cns Diseases | treats | disease | 0.85 |
| AADC Deficiency | treats | disease | 0.85 |
| ALS | treats | disease | 0.85 |
| Disease Progression | modulates | phenotype | 0.85 |
| P53 dysfunction | treats | phenotype | 0.80 |
| Motor Neuron Degeneration | treats | disease | 0.80 |
| Neuronal Structural Integrity | treats | phenotype | 0.70 |
| Alzheimer's disease | treats | disease | 0.70 |
| Amyotrophic Lateral Sclerosis | treats | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | targets | gene | 0.95 |
| SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 | investigates | analysis | 0.90 |
| Delivery Strategies | mediates | process | 0.85 |
| Lipid Nanoparticle Systems | associated_with | entity | 0.80 |
| Routes Of Administration | involved_in | process | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microgli | 0.905 | neurodegeneration | Lipid raft composition changes in synapt |
| CYP46A1 Overexpression Gene Therapy | 0.888 | neurodegeneration | Lipid raft composition changes in synapt |
| Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th | 0.695 | neurodegeneration | Neuroinflammation resolution mechanisms |
| Combination Gene Therapy Targeting RGS6 and Parkin or PINK1 | 0.317 | neurodegeneration | Does RGS6 upregulation or D2 autorecepto |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Metal Ion Homeostasis Dysregulation in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Wilson Disease Neurodegeneration: Mechanism and Therapeutic Response | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $7,500,000 |
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| Alox15/15-HpETE Aggravates Myocardial Ischemia-Reperfusion Injury by Promoting C [PMID:36987924] | Cai W, Liu L, Shi X, Liu Y, Wang J, Fang | Circulation | 2023 | 1 |
| Ferroptosis inhibitor liproxstatin-1 alleviates metabolic dysfunction-associated [PMID:36323829] | Tong J, Lan XT, Zhang Z, Liu Y, Sun DY, | Acta Pharmacol Sin | 2023 | 1 |
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistan [PMID:32106859] | Zhang H, Deng T, Liu R, Ning T, Yang H, | Mol Cancer | 2020 | 1 |
| Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548] | Hong S, Beja-Glasser VF, Nfonoyim BM, Fr | Science | 2016 | 1 |
| Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b [PMID:24293102] | Zhao Y, Bhattacharjee S, Jones BM, Hill | Mol Neurobiol | 2014 | 1 |
| ALOX15 exerts tumor-suppressive role in head and neck squamous cell carcinoma vi [PMID:41820595] | Liu A, Zhang X, Li R, Zhang Y, Yang Z, Z | Functional & integrative genom | 2026 | 0 |
| Potential Biological Processes Related to Brain SLC13A5 Across the Lifespan: Wei [PMID:41750164] | Ferreira BK, Schuck PF, Ferreira GC, Fre | Brain sciences | 2026 | 0 |
| Inhibition of Calcium-Dependent Lipid Droplets Relocation of ACSL4-PKCβ-ALOX15 C [PMID:41589658] | Hou G, Luan J, Xu X, Qin J, Ma S et al. | Adv Sci (Weinh) | 2026 | 0 |
| Inhibition of Ferroptosis in Prostatitis Model by Low Intensity Extracorporeal S [PMID:41714892] | Lin D, Li K, Kuang W, Chen Z, Zhang M | World J Mens Health | 2026 | 0 |
| Sanhua essential oil exerts antidepressant effects in breast cancer-related depr [PMID:41722126] | Li X, Xu Z, Ju P, Dong M, Wang Y et al. | Phytomedicine | 2026 | 0 |
| How cytochrome P450 enzymes in humans are involved in Parkinson's disease: a lit [PMID:41730497] | Ren B, Yan H, Han C, Sun S, Wang D, Xu Y | Neuroscience | 2026 | 0 |
| Dysregulated Cholesterol Clearance via CYP46A1 Contributes to Cerebellar Sterol [PMID:41828569] | Tapia PJ, Rivera BI, Espinoza CS, Stolze | International journal of molec | 2026 | 0 |
| Oxidative Stress Mediated by Macrophages Promotes Angiogenesis and Early Develop [PMID:41750540] | Man GCW, Borchert A, Zhang T, Hung SW, K | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Efavirenz treatment improves retinal vaso-obliteration and pathological neovascu [PMID:41810243] | Bailey B, Rudd Zhong Manis J, Seth G, Ra | Frontiers in medicine | 2026 | 0 |
| ALOX15-Derived Oxylipins Attenuate Macrophage Inflammatory Signaling Via a Gαq-P [PMID:41847922] | Hilman A, Ishii Y, Wijatniko BD, Rini DM | FASEB journal : official publi | 2026 | 0 |
| Cigarette Smoke Exacerbates Pressure Overload-Induced Right Ventricular Dysfunct [PMID:41746293] | Zhou L, Bai Q, Shi R, Zeng X, Deng J, Lu | FASEB journal : official publi | 2026 | 0 |
| Radiosynthesis and Evaluation of 18F‑Labeled Deuterated Radioligand for Positron [PMID:41704371] | Li Y, Song Z, Shi H, Zhao T, Chen J, Zho | ACS medicinal chemistry letter | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity