concept

DISEASE PROGRESSION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DISEASE PROGRESSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

75Connections

2Hypotheses

14Analyses

2Outgoing

50Incoming

0Experiments

20Debates

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💡 Concept Info

Name	DISEASE PROGRESSION

Pathway Diagram

graph TD
    DISEASE_PROGRESSION["DISEASE PROGRESSION"]
    DISEASE_PROGRESSION -->|"involved_in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Neuroinflammation["Neuroinflammation"] -->|"regulates"| DISEASE_PROGRESSION
    Extracellular_Matrix["Extracellular Matrix"] -->|"contributes to"| DISEASE_PROGRESSION
    Neuronal_Damage["Neuronal Damage"] -->|"contributes to"| DISEASE_PROGRESSION
    Neurodegeneration_Markers["Neurodegeneration Markers"] -->|"correlates_with"| DISEASE_PROGRESSION
    Poor_Cognitive_Function["Poor Cognitive Function"] -->|"correlates_with"| DISEASE_PROGRESSION
    Oligodendrocytes["Oligodendrocytes"] -->|"contributes to"| DISEASE_PROGRESSION
    Astrocytes["Astrocytes"] -->|"contributes to"| DISEASE_PROGRESSION
    NDNF_Overexpression["NDNF Overexpression"] -->|"inhibits"| DISEASE_PROGRESSION

Outgoing (2)

Target	Relation	Type	Str
Neuroinflammation	associated_with	process	0.85
Amyotrophic Lateral Sclerosis	involved_in	disease	0.85

Incoming (73)

Source	Relation	Type	Str
Donanemab	inhibits	drug	0.95
PI3K/Akt/mTOR	involved_in	pathway	0.90
39827337	exacerbate	paper	0.90
39640195	is independent biomarker of	paper	0.90
29686391	is a marker for	paper	0.90
Neuroinflammation	regulates	process	0.90
39640195	acts as independent biomarker of	paper	0.90
39640195	acted as independent biomarkers of	paper	0.90
PIKFYVE	inhibits	protein	0.90
Abnormal Stress Granule Accumulation	contributes_to	phenotype	0.90
Somatic Mutations In Hematopoietic Stem Cells	contributes_to	process	0.90
36922834	modify	paper	0.90
Extracellular Matrix	contributes_to	process	0.88
PIKFYVE inhibition	associated_with	process	0.88
Neuronal Damage	contributes_to	phenotype	0.87
Neurodegeneration Markers	correlates_with	biomarker	0.87
Cerebral Perfusion	correlates_with	biomarker	0.85
NDNF Overexpression	inhibits	process	0.85
SNCA fibril polymorphs	contributes_to	protein	0.85
Tofersen	suppresses	drug	0.85
Poor Cognitive Function	correlates_with	phenotype	0.85
Amyotrophic Lateral Sclerosis	causes	disease	0.85
Gene Therapy	modulates	drug	0.85
Astrocytes	contributes_to	cell_type	0.85
pS65-Ubiquitin	correlates_with	biomarker	0.85
Amyloid Clearance	modulates	process	0.85
Early Treatment Initiation	suppresses	mechanism	0.85
Extracellular Matrix	modulates	process	0.85
Cerebrospinal Fluid	associated_with	biomarker	0.85
SNCA	contributes_to	protein	0.85
NPY	biomarker_for	protein	0.85
Neuromodulation	modulates	process	0.85
Mitochondria	involved_in	cell_type	0.85
Gray Matter Perfusion	correlates_with	biomarker	0.85
Oligodendrocytes	contributes_to	cell_type	0.85
Metabolomic Profiles	biomarker_for	biomarker	0.82
MTOR	associated_with	pathway	0.82
Protective Genetic Variants	modulates	biomarker	0.82
M1 Microgliosis	contributes_to	cell_type	0.80
Tumor Diversity	associated_with	phenotype	0.80
Cell-To-Cell Transmission	contributes_to	process	0.80
RELN	modulates	gene	0.80
SARM1	involved_in	gene	0.75
Neuromodulation	inhibits	process	0.75
Astrogliosis	contributes_to	process	0.75
ncRNA-based therapies	suppresses	drug	0.75
Ncrna-Based Therapies	suppresses	drug	0.75
Differentially Expressed Genes	biomarker_for	biomarker	0.75
SNCA	associated_with	gene	0.70
NLRP3 inhibitor	inhibits	drug	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DNA Hypomethylation at P2RY12 Promoter Correlates with Disea	0.440	neurodegeneration	What determines P2RY12 receptor expressi
Multi-Modal Metabolic Connectivity Index for Disease Progres	0.000	-	Which metabolic biomarkers can distingui

Mentioning Analyses (14)

Scientific analyses that reference this entity

Analyze the spectrum of microglial activation states (DAM, homeostatic, inflamma

neurodegeneration | 2026-04-17 | 0 hypotheses

Gut Microbiome Analysis in Parkinson's Disease

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.778

scRNA-seq Processing and Cell Type Annotation of AD Brain

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618

Variant Annotation and Prioritization of AD Risk Loci

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.862

Survival Analysis of AD Patient Cohorts: Prognostic Markers and Time-to-Dementia

neurodegeneration | 2026-04-16 | 3 hypotheses Top: 0.895

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (20)

Multi-agent debates referencing this entity

Hypothesis debate: PLCG2 Allosteric Modulation as a Precision Therapeutic for TR

closed · Rounds: 4 · Score: 0.50 · 2026-04-26