Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPINAL MUSCULAR ATROPHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SPINAL MUSCULAR ATROPHY |
| Key Genes/Proteins | TH, TARDBP |
| Related Pathways | DNA DAMAGE RESPONSE |
Knowledge base pages for this entity
graph TD
SPINAL_MUSCULAR_ATROPHY["SPINAL MUSCULAR ATROPHY"]
SPINAL_MUSCULAR_ATROPHY -->|"regulates"| Fibroblast["Fibroblast"]
SPINAL_MUSCULAR_ATROPHY -->|"target for"| Cholesterol["Cholesterol"]
SPINAL_MUSCULAR_ATROPHY -->|"target for"| Neuron["Neuron"]
SPINAL_MUSCULAR_ATROPHY -->|"expressed in"| Apoptosis["Apoptosis"]
Gene_Therapy["Gene Therapy"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
Nursinersen["Nursinersen"] -->|"treats"| SPINAL_MUSCULAR_ATROPHY
RNA["RNA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
ALS["ALS"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
OVERVIEW["OVERVIEW"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
DEMENTIA["DEMENTIA"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
HUNTINGTON["HUNTINGTON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY
PARKINSON["PARKINSON"] -->|"target for"| SPINAL_MUSCULAR_ATROPHY| Target | Relation | Type | Str |
|---|---|---|---|
| TH | associated_with | gene | 0.50 |
| TARDBP | associated_with | gene | 0.50 |
| DNA DAMAGE RESPONSE | associated_with | pathway | 0.45 |
| CHLOROQUINE | associated_with | drug | 0.45 |
| RAPAMYCIN | associated_with | drug | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Gene Therapy | treats | process | 0.95 |
| Nursinersen | treats | drug | 0.90 |
| CRISPR-Q system | therapeutic_target | compound | 0.80 |
| MAPT | biomarker_for | gene | 0.80 |
| LDL | associated_with | gene | 0.80 |
| DNA | associated_with | gene | 0.80 |
| GFAP | biomarker_for | gene | 0.80 |
| RNA | activates | gene | 0.70 |
| TNF | associated_with | gene | 0.70 |
| LDLR | associated_with | gene | 0.70 |
| RNA | associated_with | gene | 0.70 |
| ALS | associated_with | gene | 0.70 |
| RNA | interacts_with | gene | 0.70 |
| DDC | biomarker_for | gene | 0.70 |
| IL6 | regulates | gene | 0.70 |
| TNF | activates | gene | 0.70 |
| ACTB | associated_with | gene | 0.65 |
| ALS4 | associated_with | gene | 0.65 |
| ATG7 | associated_with | gene | 0.65 |
| BECN1 | associated_with | gene | 0.65 |
| DNMT1 | associated_with | gene | 0.65 |
| GABARAP | associated_with | gene | 0.65 |
| HTT | associated_with | gene | 0.65 |
| LC3 | associated_with | gene | 0.65 |
| P62 | associated_with | gene | 0.65 |
| SETX | associated_with | gene | 0.65 |
| SMN1 | associated_with | gene | 0.65 |
| SQSTM1 | associated_with | gene | 0.65 |
| TFEB | associated_with | gene | 0.65 |
| ULK1 | associated_with | gene | 0.65 |
| WIPI2 | associated_with | gene | 0.65 |
| HUNTINGTIN | associated_with | gene | 0.65 |
| OVERVIEW | therapeutic_target | gene | 0.65 |
| AADC | therapeutic_target | gene | 0.65 |
| SMN | interacts_with | gene | 0.65 |
| SMN2 | interacts_with | gene | 0.65 |
| SMN1 | causes | gene | 0.65 |
| ALDH1A2 | contributes_to | gene | 0.65 |
| SMN | causes | gene | 0.65 |
| DNAJB1 | inhibits | gene | 0.65 |
| HSP70 | inhibits | gene | 0.65 |
| DNAJB2 | inhibits | gene | 0.65 |
| DNAJA1 | inhibits | gene | 0.65 |
| DNAJB6 | inhibits | gene | 0.65 |
| TBC1D24 | expressed_in | gene | 0.65 |
| BID | expressed_in | gene | 0.65 |
| CCNF | expressed_in | gene | 0.65 |
| MAPT | associated_with | gene | 0.65 |
| HNRNPA2B1 | associated_with | gene | 0.65 |
| SMN | associated_with | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||