pathway

Lipid Metabolism

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Lipid Metabolism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2339Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

Lipid Metabolism is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with ALS, Aging, Als. Connected to 1071 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Lipid Metabolism
Key Genes/Proteins	APOE, GENES
Related Diseases	Inflammation, Diabetes, Obesity, Als, Atherosclerosis
Linked Hypotheses	5 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Lipid_Metabolism["Lipid Metabolism"] -->|"interacts"| Mtor["Mtor"]
    Lipid_Metabolism["Lipid Metabolism"] -->|"interacts"| Lysosomal_Degradation["Lysosomal Degradation"]
    Lipid_Metabolism["Lipid Metabolism"] -->|"interacts"| Autophagy["Autophagy"]
    Lipid_Metabolism["Lipid Metabolism"] -->|"interacts"| Sphingolipid["Sphingolipid"]
    Lipid_Metabolism["Lipid Metabolism"] -->|"interacts"| Oxidative_Stress["Oxidative Stress"]
    Lipid_Metabolism["Lipid Metabolism"] -->|"interacts"| Sleep_Wake["Sleep-Wake"]
    ACTB["ACTB"] -->|"activates"| Lipid_Metabolism["Lipid Metabolism"]
    PPARA["PPARA"] -->|"activates"| Lipid_Metabolism["Lipid Metabolism"]
    CAT["CAT"] -->|"activates"| Lipid_Metabolism["Lipid Metabolism"]
    SQSTM1["SQSTM1"] -->|"activates"| Lipid_Metabolism["Lipid Metabolism"]
    style Lipid_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (321)

Target	Relation	Type	Str
Glioblastoma	promotes	disease	0.95
Phospholipid Peroxidation	regulates	mechanism	0.95
Ferroptosis	modulates	process	0.95
Flavivirus Replication	involved_in	process	0.90
Glioblastoma	contributes_to	disease	0.90
Ferroptosis Sensitivity	modulates	phenotype	0.90
Sebaceous Glands	expressed_in	cell_type	0.90
Flavivirus Infection	associated_with	disease	0.85
Alzheimer'S Disease	involved_in	disease	0.85
Flavivirus Infection	involved_in	disease	0.85
Amyloidogenesis	interacts_with	mechanism	0.85
Cognitive Resilience	contributes_to	phenotype	0.85
Myelin Composition	regulates	phenotype	0.85
Myelin Stability	regulates	phenotype	0.85
Glioblastoma Progression	associated_with	process	0.85
Preimplantation Development	associated_with	process	0.85
Tau-Mediated Degeneration	contributes_to	process	0.80
Kidney Fibrosis	contributes_to	disease	0.80
Oxidative Stress	modulates	process	0.80
Neuroinflammation	modulates	process	0.80
RUBCN	regulates	gene	0.80
Myelin Degeneration	associated_with	process	0.75
Bioenergetic Deficit	interacts_with	mechanism	0.75
Myelin Degeneration	contributes_to	process	0.75
Mtor	interacts_with	pathway	0.55
Lysosomal Degradation	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Sphingolipid	interacts_with	pathway	0.55
Oxidative Stress	interacts_with	pathway	0.55
Sleep-Wake	interacts_with	pathway	0.55
Circadian Rhythm	interacts_with	pathway	0.55
Wnt	interacts_with	pathway	0.55
Glycolysis	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Mitochondrial Function	interacts_with	pathway	0.55
Ferroptosis	interacts_with	pathway	0.55
Phagocytosis	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Hedgehog	interacts_with	pathway	0.55
Notch	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Mitophagy	interacts_with	pathway	0.55
Insulin Signaling	interacts_with	pathway	0.55
Epithelial	activates	cell_type	0.50
Hepatocyte	activates	cell_type	0.50
Stem Cell	inhibits	cell_type	0.50
Epithelial	inhibits	cell_type	0.50
Neuron	regulates	cell_type	0.50
Monocyte	associated_with	cell_type	0.50

Incoming (2018)

Source	Relation	Type	Str
APOE	associated_with	gene	1.00
Inflammation	associated_with	disease	1.00
GENES	regulates	gene	1.00
Diabetes	regulates	disease	1.00
Obesity	regulates	disease	1.00
Als	regulates	disease	1.00
Atherosclerosis	regulates	disease	1.00
Alzheimer	associated_with	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Cancer	associated_with	disease	1.00
Als	activates	disease	1.00
Cancer	regulates	disease	1.00
Alzheimer	regulates	disease	1.00
Fibrosis	activates	disease	1.00
Alzheimer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Als	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
AKT	activates	gene	1.00
Inflammation	regulates	disease	1.00
Cancer	inhibits	disease	1.00
Diabetes	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Cardiovascular	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Als	associated_with	disease	1.00
AKT	regulates	gene	1.00
PI3K	regulates	gene	1.00
Tumor	regulates	disease	1.00
INFLAMMATION	regulates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
CANCER	activates	gene	1.00
AMPK	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
CANCER	inhibits	gene	1.00
SIRT1	activates	gene	1.00
CANCER	regulates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
INFLAMMATION	activates	gene	1.00
CYTOKINES	activates	gene	1.00
IL-6	activates	gene	1.00
INFLAMMATION	therapeutic_target	gene	1.00
FERROPTOSIS	regulates	gene	1.00
APOPTOSIS	regulates	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte APOE4-Specific Lipid Metabolism Correction	0.479	neurodegeneration	Cell type vulnerability in Alzheimers Di
Sphingolipid Metabolism Reprogramming	0.443	neurodegeneration	4R-tau strain-specific spreading pattern
APOE4-Lipid Metabolism Correction	0.425	neurodegeneration	Neuroinflammation and microglial priming

Mentioning Analyses (2)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 0 hypotheses