Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HISTONE LACTYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HISTONE LACTYLATION |
Knowledge base pages for this entity
graph TD
HISTONE_LACTYLATION["HISTONE LACTYLATION"]
HISTONE_LACTYLATION -->|"mediates"| Hepatic_Stellate_Cell_Activati["Hepatic Stellate Cell Activation"]
HISTONE_LACTYLATION -->|"regulates"| Gene_Expression["Gene Expression"]
HISTONE_LACTYLATION -->|"modulates"| Inflammation["Inflammation"]
HISTONE_LACTYLATION -->|"activates"| Immunosuppressive_Transcriptio["Immunosuppressive Transcriptional Programs"]
HISTONE_LACTYLATION -->|"mediates"| Metabolic_Stress["Metabolic Stress"]
HK2["HK2"] -->|"mediates"| HISTONE_LACTYLATION
Lactate["Lactate"] -->|"mediates"| HISTONE_LACTYLATION
Histone_Acetylation["Histone Acetylation"] -->|"inhibits"| HISTONE_LACTYLATION
lactate_accumulation["lactate accumulation"] -->|"promotes"| HISTONE_LACTYLATION| Target | Relation | Type | Str |
|---|---|---|---|
| Hepatic Stellate Cell Activation | mediates | process | 0.95 |
| Gene Expression | regulates | process | 0.95 |
| Hepatic Stellate Cell Activation | activates | process | 0.94 |
| Immunosuppressive Transcriptional Programs | activates | pathway | 0.92 |
| Liver Macrophages | modulates | cell_type | 0.92 |
| Inflammation | modulates | process | 0.92 |
| CD47 | upregulates | gene | 0.90 |
| Inflammation | mediates | process | 0.90 |
| Metabolic Stress | mediates | process | 0.87 |
| Liver Macrophages | regulates | cell_type | 0.85 |
| Inflammation | regulates | process | 0.85 |
| Inflammation | promotes | process | 0.82 |
| metabolic stress | modulates | process | 0.80 |
| Inflammation | contributes_to | process | 0.80 |
| hepatocellular carcinoma | associated_with | disease | 0.78 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HK2 | mediates | gene | 0.95 |
| Lactate | mediates | compound | 0.95 |
| Lactate | substrate_of | compound | 0.95 |
| HK2 | regulates | gene | 0.90 |
| SATB2 | inhibits | gene | 0.90 |
| Histone Acetylation | inhibits | mechanism | 0.85 |
| lactate accumulation | promotes | phenotype | 0.85 |
| Histone Acetylation | modulates | mechanism | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||