gene

SATB2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SATB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

87Connections
0Hypotheses
0Analyses
50Outgoing
26Incoming

Summary

Comprehensive information on SATB2, a chromatin organizer and transcriptional regulator critical for cortical development, synaptic plasticity, and neurodegenerative disease.

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🧬 Gene Info
Gene SymbolSATB2
Full NameSpecial AT-Rich Sequence Binding Protein 2
Chromosome2q33.3
Functionis a DNA-binding protein that functions as a master chromatin organizer and transcriptional regulator.
Molecular Weight~87 kDa
Amino Acids757 aa
Exons11
PathwaysEpigenetic, Hedgehog, Notch, Tgf-Β, Wnt
UniProt IDQ9P2D8
NCBI Gene ID23305
Ensembl IDENSG00000119042
OMIM608161
GeneCardsSATB2
Human Protein AtlasSATB2
Protein Length757 amino acids
Associated DiseasesALS
InteractionsHDAC3, LCN2
KG Connections87 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SATB2 — AlphaFold Q9P2D8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SATB2 - Special AT-Rich Sequence Binding Protein 2

gene · 1663 words

PDHX Gene

gene · 3019 words

Dorsolateral Prefrontal Cortex (DLPFC) Pyramidal Neurons

cell · 2690 words

Anterior Cingulate Cortex (ACC) Pyramidal Neurons

cell · 2343 words

EBF3 — Early B-cell Factor 3

gene · 2335 words

layer-3-neurons

cell_type · 2277 words

Pathway Diagram

graph TD
    SATB2["<b>SATB2</b>"]
    Als{"Als"}
    SATB2 -->|"regulates"| Als
    Ms{"Ms"}
    SATB2 -->|"regulates"| Ms
    PIEZO1["PIEZO1"]
    SATB2 -->|"regulates"| PIEZO1
    ATF4["ATF4"]
    SATB2 -->|"associated with"| ATF4
    YAP["YAP"]
    SATB2 -->|"associated with"| YAP
    RUNX1["RUNX1"]
    SATB2 -->|"associated with"| RUNX1
    Notch(["Notch"])
    SATB2 -->|"regulates"| Notch
    Wnt(["Wnt"])
    SATB2 -->|"regulates"| Wnt
    Tgf__(["Tgf-Beta"])
    SATB2 -->|"regulates"| Tgf__
    Epigenetic(["Epigenetic"])
    SATB2 -->|"regulates"| Epigenetic
    Hedgehog(["Hedgehog"])
    SATB2 -->|"regulates"| Hedgehog
    neurodegeneration["neurodegeneration"]
    SATB2 -->|"implicated in"| neurodegeneration
    HIPPO["HIPPO"]
    HIPPO -->|"regulates"| SATB2
    TAZ["TAZ"]
    TAZ -->|"associated with"| SATB2
    RUNX2["RUNX2"]
    RUNX2 -->|"associated with"| SATB2
    style SATB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (61)

TargetRelationTypeStr
H3K9 Lactylationdownregulatesprocess0.95
LCN2associated_withgene0.95
Lung Cancersuppressesdisease0.95
Non-Small Cell Lung Cancersuppressesdisease0.92
HDAC3interacts_withprotein0.90

Incoming (26)

SourceRelationTypeStr
TAZassociated_withgene0.60
SPASTassociated_withgene0.60
COL4A1associated_withgene0.60
PDHXassociated_withgene0.60
GNAO1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found