Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SATB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive information on SATB2, a chromatin organizer and transcriptional regulator critical for cortical development, synaptic plasticity, and neurodegenerative disease.
| Gene Symbol | SATB2 |
| Full Name | Special AT-Rich Sequence Binding Protein 2 |
| Chromosome | 2q33.3 |
| Function | is a DNA-binding protein that functions as a master chromatin organizer and transcriptional regulator. |
| Molecular Weight | ~87 kDa |
| Amino Acids | 757 aa |
| Exons | 11 |
| Pathways | Epigenetic, Hedgehog, Notch, Tgf-Β, Wnt |
| UniProt ID | Q9P2D8 |
| NCBI Gene ID | 23305 |
| Ensembl ID | ENSG00000119042 |
| OMIM | 608161 |
| GeneCards | SATB2 |
| Human Protein Atlas | SATB2 |
| Protein Length | 757 amino acids |
| Associated Diseases | ALS |
| Interactions | HDAC3, LCN2 |
| KG Connections | 87 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SATB2["<b>SATB2</b>"]
Als{"Als"}
SATB2 -->|"regulates"| Als
Ms{"Ms"}
SATB2 -->|"regulates"| Ms
PIEZO1["PIEZO1"]
SATB2 -->|"regulates"| PIEZO1
ATF4["ATF4"]
SATB2 -->|"associated with"| ATF4
YAP["YAP"]
SATB2 -->|"associated with"| YAP
RUNX1["RUNX1"]
SATB2 -->|"associated with"| RUNX1
Notch(["Notch"])
SATB2 -->|"regulates"| Notch
Wnt(["Wnt"])
SATB2 -->|"regulates"| Wnt
Tgf__(["Tgf-Beta"])
SATB2 -->|"regulates"| Tgf__
Epigenetic(["Epigenetic"])
SATB2 -->|"regulates"| Epigenetic
Hedgehog(["Hedgehog"])
SATB2 -->|"regulates"| Hedgehog
neurodegeneration["neurodegeneration"]
SATB2 -->|"implicated in"| neurodegeneration
HIPPO["HIPPO"]
HIPPO -->|"regulates"| SATB2
TAZ["TAZ"]
TAZ -->|"associated with"| SATB2
RUNX2["RUNX2"]
RUNX2 -->|"associated with"| SATB2
style SATB2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| H3K9 Lactylation | downregulates | process | 0.95 |
| LCN2 | associated_with | gene | 0.95 |
| Lung Cancer | suppresses | disease | 0.95 |
| Non-Small Cell Lung Cancer | suppresses | disease | 0.92 |
| HDAC3 | interacts_with | protein | 0.90 |
| Histone Lactylation | inhibits | process | 0.90 |
| Nsclc Cell Proliferation | inhibits | phenotype | 0.90 |
| Nsclc Cell Migration | inhibits | phenotype | 0.90 |
| Epithelial-Mesenchymal Transition | inhibits | process | 0.90 |
| Cell Proliferation | inhibits | phenotype | 0.88 |
| Cell Migration | inhibits | phenotype | 0.85 |
| LCN2 | binds | protein | 0.85 |
| Epithelial-Mesenchymal Transition | suppresses | process | 0.83 |
| Epigenetic-Metabolic Crosstalk | involved_in | pathway | 0.82 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Anxiety | expressed_in | disease | 0.65 |
| PIEZO1 | regulates | gene | 0.60 |
| ATF4 | associated_with | gene | 0.60 |
| ATL1 | associated_with | gene | 0.60 |
| PDHX | associated_with | gene | 0.60 |
| SLC16A2 | associated_with | gene | 0.60 |
| GNAO1 | associated_with | gene | 0.60 |
| GAD1 | expressed_in | gene | 0.60 |
| DLG4 | expressed_in | gene | 0.60 |
| SPAST | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| YAP | associated_with | gene | 0.60 |
| RUNX1 | associated_with | gene | 0.60 |
| Notch | regulates | pathway | 0.60 |
| Wnt | regulates | pathway | 0.60 |
| Tgf-Β | regulates | pathway | 0.60 |
| Epigenetic | regulates | pathway | 0.60 |
| Hedgehog | regulates | pathway | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| NEURON | expressed_in | gene | 0.60 |
| ANXIETY | expressed_in | gene | 0.60 |
| GABA | expressed_in | gene | 0.60 |
| Synaptic Plasticity | expressed_in | pathway | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| Neuron | expressed_in | cell_type | 0.60 |
| AND | associated_with | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| DEPRESSION | expressed_in | gene | 0.60 |
| Caspase | expressed_in | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TAZ | associated_with | gene | 0.60 |
| SPAST | associated_with | gene | 0.60 |
| COL4A1 | associated_with | gene | 0.60 |
| PDHX | associated_with | gene | 0.60 |
| GNAO1 | associated_with | gene | 0.60 |
| GAD1 | expressed_in | gene | 0.60 |
| ATL1 | associated_with | gene | 0.60 |
| SLC16A2 | associated_with | gene | 0.60 |
| DLG4 | expressed_in | gene | 0.60 |
| DLG4 | biomarker_for | gene | 0.60 |
| HDAC3 | activates | gene | 0.60 |
| POLR2A | associated_with | gene | 0.60 |
| HIPPO | regulates | gene | 0.60 |
| RUNX2 | associated_with | gene | 0.60 |
| DEPRESSION | expressed_in | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ANXIETY | expressed_in | gene | 0.60 |
| GABA | expressed_in | gene | 0.60 |
| NEURON | expressed_in | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| GABA | biomarker_for | gene | 0.60 |
| LCN2 | targets | gene | 0.60 |
| RNA | targets | gene | 0.60 |
| LCN2 | activates | gene | 0.60 |
| LCN2 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||