concept

HISTONE ACETYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HISTONE ACETYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections
0Hypotheses
0Analyses
7Outgoing
7Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameHISTONE ACETYLATION
Key Genes/ProteinsHK2, APOE, SIRT6, ERK
Related DiseasesCSF

Wiki Pages (20)

Knowledge base pages for this entity

Alzheimer's Disease

disease · 5265 words

Circadian Rhythm in Neurodegeneration

mechanism · 4939 words

Epigenetic Dysregulation in Neurodegeneration

mechanism · 4376 words

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

mechanism · 4361 words

Epigenetic Alterations in Alzheimer's Disease

mechanism · 4331 words

Pathway Diagram

graph TD
    HISTONE_ACETYLATION["HISTONE ACETYLATION"]
    HISTONE_ACETYLATION -->|"activates"| memory_consolidation["memory consolidation"]
    HISTONE_ACETYLATION -->|"involved_in"| Chromatin_Remodeling["Chromatin Remodeling"]
    HISTONE_ACETYLATION -->|"inhibits"| Histone_Lactylation["Histone Lactylation"]
    HISTONE_ACETYLATION -->|"upstream_of"| PDCD1LG1["PDCD1LG1"]
    HISTONE_ACETYLATION -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    HISTONE_ACETYLATION -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    HDAC["HDAC"] -->|"regulates"| HISTONE_ACETYLATION
    APOE["APOE"] -->|"activates"| HISTONE_ACETYLATION
    EP300["EP300"] -->|"regulates"| HISTONE_ACETYLATION
    HDAC_Inhibitors["HDAC Inhibitors"] -->|"modulates"| HISTONE_ACETYLATION
    acetate["acetate"] -->|"promotes"| HISTONE_ACETYLATION
    YAP["YAP"] -->|"modulates"| HISTONE_ACETYLATION
    HDAC_Inhibition["HDAC Inhibition"] -->|"upregulates"| HISTONE_ACETYLATION

Outgoing (14)

TargetRelationTypeStr
NEURONSactivatescell_type0.65
NEURONimplicated_incell_type0.55
NICOTINAMIDEassociated_withdrug0.50
RAPAMYCINassociated_withdrug0.45
FRONTAL CORTEXassociated_withbrain_region0.45

Incoming (18)

SourceRelationTypeStr
HK2activatesgene0.65
APOEregulatesgene0.65
SIRT6regulatesgene0.60
ERKregulatesgene0.60
ASTROCYTEinhibitscell_type0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found