concept

LACTATE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LACTATE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

11Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	LACTATE
Key Genes/Proteins	AMPK, APP, BDNF, CD47
Related Diseases	AGING, ATP, AUTOPHAGY, CANCER, CELL DEATH
Related Pathways	AMPK SIGNALING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Lactate Lactylation in Neurodegeneration

mechanism · 2167 words

→

Pathway Diagram

graph TD
    LACTATE["LACTATE"]
    LACTATE -->|"causes"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    LACTATE -->|"modulates"| RAB7A["RAB7A"]
    LACTATE -->|"promotes"| CIRP["CIRP"]
    LACTATE -->|"regulates"| HADHA["HADHA"]
    LACTATE -->|"mediates"| Histone_Lactylation["Histone Lactylation"]
    LACTATE -->|"promotes"| Metastasis["Metastasis"]
    LDHA["LDHA"] -->|"regulates"| LACTATE
    SIRT1["SIRT1"] -->|"modulates"| LACTATE
    HK2["HK2"] -->|"regulates"| LACTATE
    ischemia_reperfusion_injury["ischemia-reperfusion injury"] -->|"activates"| LACTATE
    MCT1["MCT1"] -->|"interacts"| LACTATE

Outgoing (96)

Target	Relation	Type	Str
RAB7A	modulates	protein	0.95
CIRP	promotes	protein	0.95
HADHA	regulates	protein	0.95
Histone Lactylation	mediates	process	0.95
Histone Lactylation	substrate_of	process	0.95
CIRP	promotes	protein	0.95
Hepatocellular Carcinoma	associated_with	disease	0.95
Hepatocellular Carcinoma	causes	disease	0.95
Metastasis	promotes	phenotype	0.95
RAB7A lactylation	promotes	process	0.92
NUPR1	upregulates	gene	0.90
Neuroprotection	protective_against	phenotype	0.90
CD47	upregulates	gene	0.90
Hepatic Stellate Cell Activation	activates	process	0.90
CIRP	upregulates	protein	0.90
Glioblastoma Stem Cells	regulates	cell_type	0.90
RUBCN	modulates	protein	0.90
acute lung injury	promotes	disease	0.90
Glioblastoma	contributes_to	disease	0.90
RARγ	inhibits	protein	0.88
hepatic ischemia-reperfusion injury	exacerbates	disease	0.88
Glial Activation	promotes	process	0.88
sepsis-induced myocardial depression	promotes	phenotype	0.88
Glial Activation	causes	process	0.88
H3K9 Lactylation	promotes	process	0.87
Exosome Biogenesis	upregulates	process	0.87
STING	correlates_with	unknown	0.85
PSMD14	upregulates	protein	0.85
Tumor-Derived Exosome Biogenesis	regulates	process	0.85
Parkinson'S Disease	causes	disease	0.85
Cd47-Dependent Immune Evasion	mediates	process	0.85
H3K9 Lactylation	upregulates	process	0.85
H3K18 Lactylation	mediates	process	0.85
Renal Ischemia-Reperfusion Injury	promotes	disease	0.82
Acute Lung Injury	risk_factor_for	disease	0.80
LCN2	upregulates	gene	0.80
lactylation	activates	process	0.70
NLRP3	activates	protein	0.70
VEGFA	causes	gene	0.65
GLYCOLYSIS	activates	phenotype	0.65
P300	activates	gene	0.65
HK2	inhibits	gene	0.65
HK2	treats	gene	0.65
AGING	regulates	phenotype	0.65
WNT SIGNALING	inhibits	pathway	0.65
CD47	activates	gene	0.65
CD47	causes	gene	0.65
CD47	regulates	gene	0.65
BEVACIZUMAB	activates	drug	0.65
SIRT1	regulates	gene	0.65

Incoming (53)

Source	Relation	Type	Str
LDHA	regulates	protein	0.95
PKM2	associated_with	gene	0.90
Microglia/Macrophages	associated_with	cell_type	0.85
Gbm Stem Cells	associated_with	cell_type	0.85
HK2	associated_with	gene	0.85
SIRT1	modulates	protein	0.85
Rab7A	associated_with	protein	0.80
HK2	regulates	gene	0.80
ischemia-reperfusion injury	activates	process	0.70
ERK	activates	gene	0.70
LAG3	inhibits	gene	0.65
AMPK	treats	gene	0.65
ENDOTHELIAL CELLS	treats	cell_type	0.65
PYRUVATE	causes	phenotype	0.65
PKM2	causes	gene	0.65
WARBURG EFFECT	causes	phenotype	0.65
ERK	phosphorylates	gene	0.65
TUMOR MICROENVIRONMENT	interacts_with	phenotype	0.65
GLIOMA	interacts_with	disease	0.65
IDH1	produces	gene	0.65
LRP1	inhibits	gene	0.65
SIRT1	interacts_with	gene	0.65
SIRT1	causes	gene	0.65
STAT3	activates	gene	0.65
STAT3	regulates	gene	0.65
LDHA	activates	gene	0.60
HK2	causes	gene	0.60
AMPK	protects_against	gene	0.60
AMPK	causes	gene	0.60
NEURODEGENERATION	treats	phenotype	0.60
GLYCOLYSIS	causes	phenotype	0.60
OXIDATIVE STRESS	synergizes_with	phenotype	0.60
APP	targets	gene	0.60
GLYCOLYSIS	produces	phenotype	0.60
GLUTAMATE	activates	phenotype	0.60
ASTROCYTE	targets	cell_type	0.60
ASTROCYTE	treats	cell_type	0.60
MCT1	interacts_with	protein	0.60
28933272	is increased in	paper	0.60
29555943	may correlate with	paper	0.60
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
AMPK SIGNALING	associated_with	pathway	0.50
WHITE MATTER	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
GRAY MATTER	associated_with	brain_region	0.50
METFORMIN	associated_with	drug	0.50
QUERCETIN	associated_with	drug	0.45
SEMAGLUTIDE	associated_with	drug	0.45
BEVACIZUMAB	associated_with	drug	0.45
MAPK PATHWAY	associated_with	pathway	0.45

Targeting Hypotheses (11)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 4: Metabolic Coupling via Lactate-Shuttling Colla	0.895	neurodegeneration	Which specific factors in conditioned me
Dynamic Lactate-Pyruvate Ratio as Therapeutic Stratification	0.677	translational-neuroscience	Which metabolic biomarkers can distingui
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.656	neurodegeneration	What is the molecular mechanism by which
Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio	0.532	translational-neuroscience	Which metabolic biomarkers can distingui
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener	0.529	neurodegeneration	Selective vulnerability of entorhinal co

Astrocyte-Neuron Lactate Shuttle (H6): Metabolic Coupling Re	0.500	neurodegeneration	Does restoring neuronal AMPK activity re
Lactate Shuttle Pathway Enhancement	0.455	neurodegeneration	Which specific metabolic pathways in APO
Lactate-HCAR1 signaling maintains a self-reinforcing glycoly	0.427	neuroinflammation	Do microglia actually switch between gly
Astrocyte-Neuron Lactate Shuttle via SST-Mediated Metabolic	0.350	alzheimers	Closed-loop transcranial focused ultraso
Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacolog	0.308	metabolomics	Metabolomic signatures of neurodegenerat
Metabolic Reprogramming via Lactate Utilization	0.000	-	Selective vulnerability of entorhinal co

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do astrocyte-neuron metabolic interactions change during disease progression

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.541

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
miR-375 protects against acetaminophen-induced acute liver failure by orchestrat [PMID:40598772]	Wang Y, Liu J, Zhu S, Hu S, Chen X, Mand	Mol Ther	2025	1
Defective thyroid hormone transport to the brain leads to astroglial alterations [PMID:39097035]	Guillén-Yunta M, García-Aldea Á, Valcárc	Neurobiol Dis	2024	1
The SLC16 gene family - structure, role and regulation in health and disease. [PMID:23506875]	Halestrap AP	Mol Aspects Med	2013	1
Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroi [PMID:39930360]	Carrasco M, Guzman L, Olloquequi J, Cano	Molecular medicine (Cambridge,	2025	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Tiratricol: First Approval. [PMID:40549098]	["Lamb Y"]	Drugs	2025	0
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. [PMID:40680733]	Ge Y, Dou T, Nguyen TU, Yadav GP, Wensel	Cell	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
The interactions between monocarboxylate transporter genes MCT1, MCT2, and MCT4 [PMID:39934699]	Maculewicz E, Mastalerz A, Garbacz A, Mr	BMC genomics	2025	0
Pathological remodeling of reactive astrocytes: Involvement of DNA methylation a [PMID:38943350]	Cuautle DG, Donna S, Cieri MB, Villarrea	Journal of neurochemistry	2024	0
Adrenergic regulation of astroglial aerobic glycolysis and lipid metabolism: Tow [PMID:37094775]	["Zorec R", "Vardjan N"]	Neurobiology of disease	2023	0
Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish. [PMID:36150888]	Wasserman-Bartov T, Admati I, Lebenthal-	The Journal of neuroscience :	2022	0
The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. [PMID:34097251]	Sohrabi E, Moslemi M, Rezaie E, Nafissi	Genes & genomics	2021	0
Thyroid Hormone Transporters. [PMID:31754699]	["Groeneweg S", "van Geest F", "Peeters	Endocrine reviews	2020	0
Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis [PMID:31797746]	["Admati I", "Wasserman-Bartov T", "Tovi	Thyroid : official journal of	2020	0
Disease characteristics of MCT8 deficiency: an international, retrospective, mul [PMID:32559475]	Groeneweg S, van Geest FS, Abacı A, Alca	The lancet. Diabetes & endocri	2020	0
Oligodendroglia metabolically support axons and contribute to neurodegeneration. [PMID:22801498]	Lee Y, Morrison BM, Li Y, Lengacher S, F	Nature	2012	0
Nonbiological maternal risk factor for low birth weight on Latin America: a syst [PMID:23386023]	["da Silva T"]	Einstein (Sao Paulo, Brazil)	2012	0
Thyroid hormone transporters in the brain. [PMID:20879691]	Braun D, Wirth EK, Schweizer U	Reviews in the neurosciences	2010	0
Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome [PMID:16849530]	["Eckerdt F", "Strebhardt K"]	Cancer research	2006	0

Debates (1)

Multi-agent debates referencing this entity

How do astrocyte-neuron metabolic interactions change during disease progression

closed · Rounds: 4 · Score: 0.93 · 2026-04-04

Related Research

Hypotheses and analyses mentioning LACTATE in their description or question text

Astrocyte-Neuron Lactate Shuttle (H6): Metabolic Coupling Restoration

Score: 0.500 · neurodegeneration · 2026-04-25

Astrocyte-specific MCT1 overexpression restores lactate shuttle to re-establish astrocyte-neuron metabolic cross-feeding

Lactate Shuttle Pathway Enhancement

Score: 0.455 · neurodegeneration · 2026-04-27

Enhance MCT1/MCT2 expression to convert metabolic lactate overproduction into alternative fuel source for high-demand st

Lactate-HCAR1 signaling maintains a self-reinforcing glycolytic priming loop

Score: 0.427 · neuroinflammation · 2026-04-21

## Mechanistic Overview Lactate-HCAR1 signaling maintains a self-reinforcing glycolytic priming loop starts from the cla

Astrocyte-Neuron Lactate Shuttle via SST-Mediated Metabolic Coupling (Deprioriti

Score: 0.350 · alzheimers · 2026-04-28

tFUS-activated EC-II SST interneurons trigger astrocytic Ca²⁺ waves via ATP release, stimulating glycolysis and lactate

Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacological Activation of M

Score: 0.308 · metabolomics · 2026-04-25

Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacological Activation of Monocarboxylate Transporters

Metabolic Reprogramming via Lactate Utilization

Score: 0.000 · unknown disease · 2026-04-28

Provide alternative energy substrates for stellate neurons through enhanced lactate metabolism when glucose utilization