concept

MICROTUBULE STABILITY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MICROTUBULE STABILITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

2Hypotheses

1Analyses

9Outgoing

28Incoming

0Experiments

3Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	MICROTUBULE STABILITY

Pathway Diagram

graph TD
    MICROTUBULE_STABILITY["MICROTUBULE STABILITY"]
    MICROTUBULE_STABILITY -->|"involved_in"| Nervous_System_Development["Nervous System Development"]
    MICROTUBULE_STABILITY -->|"involved_in"| Nervous_System_Maintenance["Nervous System Maintenance"]
    MICROTUBULE_STABILITY -->|"regulates"| Neuronal_Cytoskeletal_Architec["Neuronal Cytoskeletal Architecture"]
    MAPT["MAPT"] -->|"inhibits"| MICROTUBULE_STABILITY
    MAP6["MAP6"] -->|"activates"| MICROTUBULE_STABILITY
    MAP6_Rich_Microtubule_Domains["MAP6-Rich Microtubule Domains"] -->|"correlates_with"| MICROTUBULE_STABILITY
    TAU["TAU"] -->|"modulates"| MICROTUBULE_STABILITY

Outgoing (9)

Target	Relation	Type	Str
Neuronal Cytoskeletal Architecture	regulates	process	0.90
Nervous System Development	involved_in	process	0.90
NEURODEGENERATION	associated_with	entity	0.90
Nervous System Maintenance	involved_in	process	0.90
neurodegenerative diseases	implicated_in	disease	0.85
Nervous System Development	contributes_to	process	0.85
Nervous System Maintenance	contributes_to	process	0.85
Neurodegenerative Diseases	associated_with	disease	0.85
morphological plasticity	mediates	phenotype	0.80

Incoming (28)

Source	Relation	Type	Str
MAP6	activates	gene	0.95
MAPT	inhibits	gene	0.95
MAP6-Rich Microtubule Domains	correlates_with	phenotype	0.90
MAPT	regulates	protein	0.90
MAP6	upregulates	protein	0.90
MAPT	modulates	gene	0.90
MAP6	regulates	gene	0.90
microtubule-targeting drugs	modulates	drug	0.90
TAU	modulates	entity	0.90
MAP6	modulates	entity	0.90
STMN2	modulates	protein	0.90
Acetylated Tubulin	mediates	protein	0.88
MAP6	promotes	protein	0.88
Microtubule Domains	associated_with	process	0.85
LRRK2	regulates	gene	0.85
Hdac Inhibitors	promotes	drug	0.85
TAU	regulates	protein	0.85
Epothilone D	associated_with	drug	0.80
MAP6	regulates	protein	0.80
TAU	regulates	entity	0.80
Microtubule-Related Proteins	regulates	protein	0.80
microtubule domains	modulates	protein	0.80
tau	regulates	protein	0.80
HDAC Inhibitors	associated_with	drug	0.80
HDAC Inhibitors	upregulates	drug	0.75
GFAP	associated_with	gene	0.70
STMN2 restoration	restores	process	0.70
MAPT	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC6 Selective Inhibition to Restore Acetylation Balance an	0.643	structural-biology	What is the atomic-resolution structure
HDAC6 Inhibition for Dual Restoration of Microtubule Stabili	0.484	neurodegeneration	Which tau PTMs are both disease-specific