gene

SYNAPSES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPSES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections
0Hypotheses
3Analyses
0Outgoing
1Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolSYNAPSE
Full NameSynaptic Junction (cellular structure)
AliasesSynaptic cleft
Protein TypeCellular structure
FunctionSpecialized intercellular junction enabling electrochemical signal transmission between neurons. Comprises presynaptic terminal, synaptic cleft, and postsynaptic density. Critical for learning, mem...
PathwaysNeurotransmitter release, LTP, LTD, AMPA/NMDA signaling
GeneCardsSYNAPSE
Human Protein AtlasSYNAPSE
SourceTarget
Inferior olivePurkinje cells
Axon collateralsDeep nuclei
InterneuronsModulatory
Associated DiseasesAlzheimer's disease, Parkinson's disease, Schizophrenia, ALS
KG Connections1 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Climbing Fiber Synapses

cell · 1553 words

cbs-psp-daily-action-plan

therapeutic · 30834 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Novel Therapy Index

idea · 10647 words

Atypical Parkinsonism

disease · 6876 words

Pathway Diagram

graph TD
    SYNAPSES["SYNAPSES"] -->|"causes"| RAB7["RAB7"]
    style RAB7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"regulates"| PHAGOCYTOSIS["PHAGOCYTOSIS"]
    style PHAGOCYTOSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -.->|"inhibits"| BDNF["BDNF"]
    style BDNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"causes"| COMPLEMENT_ACTIVATION["COMPLEMENT ACTIVATION"]
    style COMPLEMENT_ACTIVATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"causes"| SYNAPTIC_LOSS["SYNAPTIC LOSS"]
    style SYNAPTIC_LOSS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -.->|"inhibits"| LYSOSOME["LYSOSOME"]
    style LYSOSOME fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SYNAPSES["SYNAPSES"] -->|"causes"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"protects against"| SYNAPSES["SYNAPSES"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MICROGLIA["MICROGLIA"] -->|"phagocytoses"| SYNAPSES["SYNAPSES"]
    style MICROGLIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    SPP1["SPP1"] -->|"induces"| SYNAPSES["SYNAPSES"]
    style SPP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    GLUTAMATE["GLUTAMATE"] -->|"produces"| SYNAPSES["SYNAPSES"]
    style GLUTAMATE fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    OLIGODENDROCYTE["OLIGODENDROCYTE"] -->|"activates"| SYNAPSES["SYNAPSES"]
    style OLIGODENDROCYTE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style SYNAPSES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (9)

SourceRelationTypeStr
MICROGLIAinteracts_withcell_type0.64

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.455

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

neuro-oncology | 2026-04-13 | 0 hypotheses

What determines the selectivity of complement-mediated synaptic elimination in p

synaptic biology | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found