PANORAMA1: Panobinostat + Bortezomib + Dexamethasone vs Placebo + Bortezomib + Dexamethasone in Relapsed Multiple Myelom
🧬 N/A
🏥 Multiple myeloma
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Randomized, double-blind, placebo-controlled phase 3 trial with 21-day treatment cycles. Panobinostat 20mg orally on day...
Expected: Improved progression-free survival with panobinostat combination based on preclinical synergistic an...
Simvastatin effects on portal hypertension in cirrhotic patients
🧬 N/A
🏥 cirrhotic portal hypertension
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
**Study Title:** Randomized, Double-Blind, Placebo-Controlled Phase II/III Clinical Trial of Simvastatin for Reduction o...
Expected: **Primary Endpoint:** 22-28% of simvastatin-treated patients will achieve ≥20% HVPG reduction or HVP...
Clinical characterization of GABRA1/GABRG2 microdeletion patient
🧬 GABRA1, GABRG2
🏥 epilepsy with optic atrophy
🔗 1 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### Phase 1: Initial Clinical Assessment (Day 0)
Expected: **aCGH reveals exact breakpoints:** Microdeletion spans 142-158kb on chromosome 5q34, encompassing G...
Phase I trial of NP137 in advanced endometrial cancer
🧬 NTN1
🏥 advanced endometrial carcinoma
🔗 1 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### Phase I Trial of NP137 in Advanced Endometrial Cancer
Expected: **DLT Rate:** ≤1/6 patients (16.7%) will experience a dose-limiting toxicity at Dose Level 1 (8 mg/k...
FK866 efficacy in IBD patient-derived lamina propria cells
🧬 NAMPT
🏥 Inflammatory bowel disease
🔗 1 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### PHASE 1: Patient Recruitment and Tissue Acquisition (Day -14 to Day 0)
Expected: **FK866 will suppress TNF-α release with IC₅₀ between 1-10 nM.** In IBD patient LPMNCs stimulated wi...
Wellspent App RCT for Problematic Social Media Use
🧬 N/A
🏥 problematic social media use
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Randomized controlled trial with 1:1 allocation to intervention vs control groups. Intervention group received Wellspent...
Expected: Reduction in problematic social media use, increased self-efficacy, and decreased daily screen time ...
ACEs and Motoric Cognitive Risk Syndrome in Chinese Older Adults
🧬 N/A
🏥 motoric cognitive risk syndrome
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Cross-sectional analysis using CHARLS data. Assessment of 12 ACE indicators across categories. MCR diagnosis based on co...
Expected: Higher prevalence of MCR in individuals with more ACEs, with depression and chronic pain serving as ...
Preinjury ACE-I/ARB exposure and outcomes in transfused trauma patients
🧬 N/A
🏥 trauma
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Retrospective analysis comparing trauma patients receiving blood transfusions who had preinjury ACE-I/ARB exposure versu...
Expected: Based on previous sepsis research showing improved mortality with ACE-I/ARB use, researchers expecte...
Intensive Medical Treatment vs Usual Care in Women with ANOCA/INOCA
🧬 N/A
🏥 angina with no obstructive coronary artery disease (ANOCA/INOCA)
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Randomized controlled trial with participants assigned to intensive medical treatment (high-intensity statin + ACE inhib...
Expected: Reduction in major adverse cardiovascular events with intensive medical treatment compared to usual ...
rTMS for preventing chronic postsurgical pain in thoracoscopic surgery
🧬 N/A
🏥 chronic postsurgical pain
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Randomized controlled trial with 286 patients screened, 230 randomized to active or sham rTMS targeting left DLPFC (10 H...
Expected: Reduction in CPSP incidence, improved anxiety and depression scores, decreased inflammatory biomarke...
Reproductive fitness analysis of psychiatric disorders in Swedish population
🧬 N/A
🏥 schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, substance abuse
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Population-based analysis using Swedish Multi-Generation Register and Hospital Discharge Register. Measured fecundity of...
Expected: Determine reproductive fitness patterns across psychiatric disorders and evaluate selection pressure...
KEEPS Continuation: Long-term effects of menopausal hormone therapy on AD biomarkers
🧬 APOE
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Participants from the original KEEPS trial were recontacted 10 years after completion. Amyloid beta burden was assessed ...
Expected: The study hypothesized that imaging biomarkers would reveal early detection of evolving brain pathol...
Meta-analysis of physical activity interventions on cognitive function in AD
🧬 N/A
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Systematic review and meta-analysis following PRISMA guidelines. Searched PubMed, Web of Science, Embase, Cochrane Libra...
Expected: Physical activity interventions would improve cognitive function as measured by MMSE scores in AD pa...
Dairy intake and dementia risk in Malmö Diet and Cancer cohort
🧬 APOE
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Prospective cohort study with comprehensive dietary assessment at baseline (7-day food diary, food frequency questionnai...
Expected: Investigation of differential associations between high-fat vs low-fat dairy products and dementia r...
Mediterranean diet app intervention for atrial fibrillation patients
🧬 N/A
🏥 atrial fibrillation
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
**Study Title:** Mobile Health Mediterranean Diet Intervention for Atrial Fibrillation Patients: A Randomized Controlled...
Expected: **Retention Rate:** ≥85% (51/60) of randomized participants complete the Week 24 assessment in both ...
Plant-based dietary patterns and Alzheimer's disease risk in multiethnic cohort
🧬 N/A
🏥 Alzheimer's disease and related dementias
🔗 3 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Prospective longitudinal cohort study using food frequency questionnaires at baseline (1993-1996) and 10-year follow-up ...
Expected: Higher quality plant-based diets (higher PDI and hPDI) were expected to be associated with lower ADR...
Real-world safety study of Lecanemab in Japanese AD patients
🧬 N/A
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Establish human patients cohorts for Alzheimer's disease and predefine inclusion, exclusion, and quality-control criteri...
Expected: Lower incidence of adverse events in Japanese population compared to global cohorts based on previou...
Plasma ATN biomarkers across AD continuum in Chilean cohort
🧬 APP, MAPT
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Establish Chilean older adults (n=318) with CU, SCC, MCI, and ADD cohorts for Alzheimer's disease and predefine inclusio...
Expected: Progressive decline in Aβ42/Aβ40 ratio and elevations in p-tau217 and GFAP across clinical continuum...
Mobile App-Based Intervention for BPSD in Community-Dwelling Dementia Patients
🧬 N/A
🏥 dementia with behavioral and psychological symptoms
🔗 3 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Single-blinded randomized controlled trial with 36 dyads randomized to intervention (mobile app for 4 weeks) or control ...
Expected: The intervention targeting the nominated disease mechanism shifts overall BPSD, agitated behavior, a...
Longitudinal dietary change analysis and ADRD risk over 10 years
🧬 N/A
🏥 Alzheimer's disease and related dementias
🔗 3 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Establish human patients cohorts for Alzheimer's disease and related dementias and predefine inclusion, exclusion, and q...
Expected: Increases in unhealthful plant-based diet scores over time were expected to increase ADRD risk, whil...
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Concomitant NPH
🧬 AQP1/AQP4/HCRTR1
🏥 Alzheimer's Disease
🔗 5 hyp
💰 $6,550,000
⏱ 49mo
✅ 0.50
✨ 0.50
## PROTOCOL: CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Concomitant NPH
Expected: ## EXPECTED OUTCOMES
Literature Review of TRT-Induced Erythrocytosis Risk
🧬 N/A
🏥 hypogonadism
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Literature review performed through PubMed database searching for studies on testosterone replacement therapy and erythr...
Expected: Documentation of increased risk for erythrocytosis in men receiving TRT and identification of risk f...
Literature Review of TRT-Induced Erythrocytosis Risk
🧬 N/A
🏥 hypogonadism
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Literature review through PubMed database search focusing on TRT, erythrocytosis, and polycythemia studies
Expected: Quantification of erythrocytosis risk associated with TRT and identification of mechanisms underlyin...
sEV angiogenic properties in cardiovascular risk patients
🧬 N/A
🏥 type 2 diabetes, obesity, ischemic disease
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
sEV isolation from serum, in-vitro and in-vivo angiogenic assays across patient groups
Expected: Different angiogenic properties between patient groups, identification of predictive biomarkers
ROC analysis for sEV effectiveness prediction
🧬 miR-130a
🏥 cardiovascular disease
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
# ROC Analysis for sEV Effectiveness Prediction Protocol
Expected: ## Primary Outcomes
ROC curve analysis for predicting sEV ineffectiveness
🧬 miR-130a
🏥 type 2 diabetes mellitus, obesity, ischemic disease
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
ROC curve analysis using miR-130a and TGF-β content measurements in series
Expected: development of predictive model for sEV effectiveness
Phenobarbital treatment efficacy study
🧬 GABRA1, GABRG2
🏥 intractable epilepsy
🔗 1 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
phenobarbital treatment with EEG monitoring
Expected: effective seizure control with phenobarbital
Duloxetine treatment for anxiety/depression after rotator cuff repair
🧬 N/A
🏥 anxiety and depression comorbid with rotator cuff tears
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Randomized controlled trial with three groups based on HADS scores. Duloxetine administered orally from evening of surge...
Expected: Improved clinical outcomes, reduced anxiety and depression, better range of motion and functional sc...
HiSense Taxi App RCT for Disability Sensitivity Training
🧬 N/A
🏥 N/A
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Randomized controlled trial with repeated measures design. Participants randomly assigned to intervention group (HiSense...
Expected: Improved knowledge, empathy, and self-efficacy among taxi drivers in the intervention group compared...
CXCL10 biomarker analysis for CPSP prediction
🧬 CXCL10
🏥 chronic postsurgical pain
🔗 3 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Serum CXCL10 measurement in trial participants, ROC analysis for predictive accuracy, comparison between active and sham...
Expected: Lower CXCL10 levels in active rTMS group, good predictive accuracy for CPSP