Sevoflurane-induced neurotoxicity (SIN) rat model
🧬 C1qa
🏥 perioperative neurocognitive disorders
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
**Phase 1: Animal Preparation and Anesthesia Protocol** — Week 1
Expected: 1. Primary: Prolonged sevoflurane will increase MWM escape latency by >50% and reduce probe trial ti...
Bmal1 knockout in mPFC excitatory neurons
🧬 BMAL1,HOMER1A,CAMK2A
🏥 depression
🔗 2 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### PHASE 1: Pre-Surgical Preparation & Baseline Assessment (Weeks 1–2)
Expected: **Conditional Bmal1 knockout efficiency**: Cre-mediated excision will reduce Bmal1 mRNA by **78–85%*...
Chi3l1 deletion in APP/PS1 mouse model of Alzheimer's disease
🧬 Chi3l1
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### Study Design
Expected: **Amyloid plaque burden (Thioflavin-S)** in APP/PS1;Chi3l1^-/- will be 35–45% lower than APP/PS1;Chi...
Myricanol treatment in HFD-induced hyperlipidemic C57BL/6J mice
🧬 ACSL1, SCD1, PPARγ
🏥 hyperlipidemia
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
8-week HFD induction followed by 25-day treatment with myricanol (100 or 150 mg/kg) or rosiglitazone (0.78 mg/kg). Multi...
Expected: Reduction in serum lipid levels, decreased hepatic lipid accumulation, weight loss, and modulation o...
PS-NMP shape-dependent colonic barrier damage in mice
🧬 N/A
🏥 intestinal barrier dysfunction
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
120 five-week-old male C57BL/6J mice divided into seven groups and orally exposed to different doses of PS-NMPs (beads a...
Expected: Different shaped PS-NMPs would cause varying degrees of intestinal barrier damage with distinct mole...
Curcumin-Licorice Combination in D-galactose/Sodium Nitrite AD Model
🧬 N/A
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Mice received D-galactose/sodium nitrite to induce AD pathology, then treated with curcumin (100 mg/kg), G. glabra (100 ...
Expected: Synergistic improvement in cognitive function and reduction in neuroinflammation with combination th...
Electroacupuncture ST37 treatment for DSS-induced colitis in mice
🧬 CHAT, CHRNA7
🏥 colitis
🔗 3 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Mice received 2.5% DSS solution for 7 days to induce colitis, followed by electroacupuncture treatment at ST37 acupoint....
Expected: EA treatment was expected to and did reduce colitis severity, decrease pro-inflammatory cytokines, a...
AECII-specific HMGCS2 overexpression in mouse pulmonary fibrosis
🧬 HMGCS2
🏥 idiopathic pulmonary fibrosis
🔗 4 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### Phase 1: Animal Model Preparation & Gene Delivery (Days 0-14)
Expected: **HMGCS2 overexpression validation**: AAV-HMGCS2 group will show ≥3.2-fold increase in lung HMGCS2 m...
ABT263 treatment in sublethally irradiated mice
🧬 N/A
🏥 radiation-induced premature aging
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### Study Design Overview
Expected: **Survival**: 100% survival in sham groups; ≥85% survival in TBI groups (ABT263 may slightly reduce ...
Long-term perampanel treatment in A53T BAC-SNCA mice with PFF injection
🧬 SNCA
🏥 Lewy body disease
🔗 1 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
### Study Overview
Expected: **Motor deficit onset:** Vehicle-treated A53T/PFF mice will show significant rotarod impairment by 3...
Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice
🧬 ASC
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Establish APP/PS1 transgenic mice (8 months old) cohorts for Alzheimer's disease and predefine inclusion, exclusion, and...
Expected: The intervention targeting ASC shifts Cognitive function and AD-like pathology markers in the predic...
CD2AP downregulation in brain endothelial cells - memory function
🧬 CD2AP
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Establish mice cohorts for Alzheimer's disease and predefine inclusion, exclusion, and quality-control criteria before i...
Expected: The intervention targeting CD2AP shifts memory function impairment in the predicted direction relati...
P2RY12 inhibition in atherosclerosis mouse model
🧬 P2RY12
🏥 atherosclerosis
🔗 2 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Animals: ApoE-/- mice (C57BL/6 background), 8-10 weeks old, n=15 per group (vehicle, clopidogrel 10mg/kg/day, ticagrelor...
Expected: Quantitative predictions: (1) Vehicle HFD group: aortic root plaque area 400,000-500,000 μm², 60-70%...
Spp1 knockout prevents synaptic loss in AD mouse models
🧬 Spp1
🏥 Alzheimer's disease
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
**Phase 1: Generation of Spp1 Knockout AD Mouse Models** — Weeks 1-4
Expected: 1. Primary: Spp1-/-;5xFAD mice show 60-80% preservation of hippocampal synaptic density compared to ...
Sevoflurane-induced neurotoxicity (SIN) model in rats
🧬 C1qa
🏥 perioperative neurocognitive disorders (PND)
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Prolonged sevoflurane anesthesia exposure followed by behavioral testing (Morris water maze, elevated plus maze, open fi...
Expected: Prolonged anesthesia would cause neuroinflammation and complement-mediated synaptic elimination lead...
Microglial depletion rescue experiment
🧬 N/A
🏥 perioperative neurocognitive disorders
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Microglial depletion followed by prolonged sevoflurane anesthesia and assessment of neuroinflammation, complement activa...
Expected: Prevention of neuroinflammation, complement activation, synaptic loss, and behavioral deficits
C1q neutralization experiment
🧬 C1qa
🏥 perioperative neurocognitive disorders
🔗 5 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
C1q neutralization followed by prolonged sevoflurane anesthesia and assessment of complement activation and synaptic int...
Expected: Reduced complement activation and preserved synaptic integrity
TDP-43 mutant mouse model cGAS/STING pathway analysis
🧬 TARDBP
🏥 amyotrophic lateral sclerosis
🔗 4 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Analysis of TDP-43 mutant mice with pharmacologic inhibition or genetic deletion of cGAS/STING components, assessment of...
Expected: cGAS/STING inhibition reduces neuroinflammation in TDP-43 mutant mice
Continental-scale satellite tracking of Arctic peregrine falcons
🧬 N/A
🏥 N/A
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
satellite GPS tracking of 56 individuals from 6 Arctic breeding populations throughout annual migration cycles
Expected: identification of distinct migration routes and population-specific migration patterns
Continental-scale satellite tracking of peregrine falcon migration
🧬 N/A
🏥 N/A
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
satellite tracking of 56 peregrine falcons from 6 Arctic breeding populations across Eurasia
Expected: identification of distinct migration routes and understanding of route formation and maintenance
Muscle-specific Tug knockout mice analysis
🧬 Aspscr1/TUG
🏥 diabetes/metabolic dysfunction
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Muscle-specific gene knockout using Cre-lox system, metabolic phenotyping, glucose uptake measurements
Expected: Impaired glucose uptake and altered energy expenditure due to loss of TUG-mediated GLUT4 regulation
Constitutive TUG cleavage mouse model
🧬 Aspscr1/TUG
🏥 metabolic regulation
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Transgenic mouse generation, gene expression analysis, metabolic measurements, nuclear localization studies
Expected: Enhanced expression of thermogenic genes like sarcolipin and UCP1, increased energy expenditure
PTEC-specific RUBCN knockout mice phenotype analysis
🧬 RUBCN
🏥 kidney injury/metabolic syndrome
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Generation of tissue-specific knockout mice, histological analysis of kidney tissue, metabolic profiling, assessment of ...
Expected: Protection from kidney injury due to enhanced autophagy
Muscle-specific Tug knockout mice study
🧬 Tug (Aspscr1)
🏥 Diabetes/metabolic dysfunction
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Generation of muscle-specific knockout mice, metabolic phenotyping, glucose uptake assays, gene expression analysis
Expected: Reduced glucose uptake and altered energy expenditure due to loss of TUG cleavage pathway
Muscle-specific constitutive TUG cleavage mice study
🧬 Tug (Aspscr1)
🏥 Metabolic regulation
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Generation of constitutive cleavage model, metabolic analysis, gene expression profiling, thermogenesis measurements
Expected: Enhanced thermogenesis and lipid oxidation due to continuous TUG C-terminal product activity
PTEC-specific RUBCN knockout mice phenotyping
🧬 RUBCN
🏥 acute kidney injury and metabolic syndrome
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
Generated conditional knockout mice with PTEC-specific RUBCN deletion, performed ischemia-reperfusion injury models, ana...
Expected: Expected protection from kidney injury due to enhanced autophagy
TREK-1 regulation of conventional outflow facility in mouse eyes
🧬 KCNK2 (TREK-1)
🏥 ocular hypertension
🔗 2 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
**Phase 1: Animal Preparation and Ethical Approval** -- Days 1-3
Expected: 1. Baseline outflow facility in mouse eyes will range from 0.8-1.5 μL/min/mmHg, consistent with publ...
TREK-1 effects on IOP in DEX-induced mouse OHT model
🧬 KCNK2 (TREK-1)
🏥 dexamethasone-induced ocular hypertension
🔗 2 hyp
💰 N/A
⏱ N/A
✅ 0.00
✨ 0.00
**Phase 1: Animal Preparation and DEX-Induced OHT Model** -- Days 1-14
Expected: 1. DEX treatment will induce significant IOP elevation (18-25 mmHg) compared to baseline (8-12 mmHg)...