Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ager: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | AGER |
| Full Name | RAGE |
| Chromosome | 6p21.3 |
| Protein Type | Receptor |
| Target Class | Protein |
| Function | RAGE is a multi-ligand receptor that binds: - Advanced glycation end products (AGEs) - HMGB1 (High Mobility Group Box 1) - S100B protein - Amyloid-beta fibrils - DNA release from damaged cells |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade |
| Druggability | Medium (0.50) |
| Clinical Stage | Phase I |
| Pathways | NF-κB, MAPK |
| UniProt ID | Q15120 |
| NCBI Gene ID | 177 |
| OMIM | 600841 |
| GeneCards | AGER |
| Human Protein Atlas | AGER |
| Associated Diseases | neurodegeneration |
| Interactions | HSPA1A, HSPA1B |
| SciDEX Target | View Target Profile |
| SciDEX Hypotheses | Blocking AGE-RAGE Signaling in Enteric Glia to Pre |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
AGER["AGER"]
AGER -->|"binds"| Amyloid_Beta["Amyloid Beta"]
AGER -->|"activates"| Microglial_Activation["Microglial Activation"]
AGER -->|"mediates"| Microglia_Activation["Microglia Activation"]
AGER -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
AGER -->|"studied_in"| neurodegeneration["neurodegeneration"]
AGER -->|"implicated in"| AD["AD"]
AGER -->|"implicated in"| ALI["ALI"]
Genes["Genes"] -->|"references"| AGER
Proteins["Proteins"] -->|"references"| AGER
RAGE__Receptor_for_Advanced_Gl["RAGE (Receptor for Advanced Glycation End Products) Modulator Therapy"] -->|"references"| AGER
TIA1L_Protein["TIA1L Protein"] -->|"references"| AGER| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | implicated_in | disease | 0.50 |
| HSPA1A | interacts_with | protein | 0.50 |
| HSPA1B | interacts_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-8f285020 | targets_gene | hypothesis | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||