gene 1,009 words KG: FER 2026-03-24
kind:genesection:genesstate:published
Contents

FER Gene

🧬 Gene Info
Gene SymbolFER
Full NameFER Proto-Oncogene, Tyrosine Kinase
Chromosome5q31.2
Protein TypeReceptor
FunctionThe FER gene encodes a non-receptor tyrosine kinase (Fer) that belongs to the FPS/FES family of tyrosine kinases.
Primary Expressionthe brain and plays important roles in neuronal signaling, synaptic function, and cell adhesion[@fer2000]
PathwaysFerroptosis, Oxidative Stress
UniProt ID[P16591](https://www.uniprot.org/uniprot/P16591)
Ensembl IDENSG00000151422
GeneCardsFER
Human Protein AtlasFER
Associated DiseasesStroke
InteractionsNFE2L2, ALOX15, SOX9, MMP3, MMP1, HMOX1
KG Connections209 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Blood-Brain Barrier SPM Shuttle System
Score: 0.55
Extracellular Matrix Stiffness Modulation
Score: 0.43
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.37
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.47

Related Analyses (14)

Mitochondrial transfer between neurons and glia
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
BNIP3 Gene
gene · KG edge: activates
BECN1 Gene
gene · KG edge: activates
BCL2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

FER regulates GPX4
FER regulates SLC7A11
FER activates NFE2L2
FER activates ALOX15
FER activates SOX9
FER activates MMP3
FER activates MMP1
FER activates HMOX1
FER inhibits GPX4
FER inhibits MMP1