protein 953 words KG: NSFPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

NSF Protein

🔬 Protein Info
Gene SymbolNSF
Full NameN-Ethylmaleimide Sensitive Fusion Protein
Chromosome17q21.31
Protein FamilyAAA ATPase family
FunctionNSF is a member of the AAA+ (ATPases Associated with diverse cellular Activities) protein family that functions as a molecular chaperone for SNARE complex recycling
Primary Expressionall eukaryotic cells, with high expression in neurons - Protein Complexes: Forms hexameric complexes and interacts with alpha
Subcellular LocalizationCytosol, Golgi apparatus, presynaptic terminals
Molecular Weight~66 kDa per monomer
PathwaysApoptosis, Cell Cycle
UniProt IDP46459
NCBI Gene ID4900
Ensembl IDENSG00000134574
OMIM163580
GeneCardsNSF
Human Protein AtlasNSF
Associated Diseasesepilepsy
Known Drugs/Compoundsrapamycin
InteractionsRIPK1, SNAP25, AND, RNA, TRPML1, SNARE
KG Connections102 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (13)

AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.59
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.45
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.43

Related Analyses (9)

Mitochondrial transfer between neurons and glia
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in