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The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.
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The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system.
["Ji C", "Kim H", "Lee M", "Heo A", "Park D", "Lim S", "Shin S", "Ganipisetti S", "Yang W", "Jung C"]
Abstract
Targeted protein degradation allows targeting undruggable proteins for therapeutic applications as well as eliminating proteins of interest for research purposes. While several degraders that harness the proteasome or the lysosome have been developed, a technology that simultaneously degrades targets and accelerates cellular autophagic flux is still missing. In this study, we develop a general chemical tool and platform technology termed AUTOphagy-TArgeting Chimera (AUTOTAC), which employs bifun...
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