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Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
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ID: paper-38685916
📄 Paper Details
Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
["Kuemper S", "Cairns A", "Birchall K", "Yao Z", "Large J"]
Abstract
Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in clinical trials and molecular glues such as immunomodulatory imide drugs (IMiDs) already well established in the treatment of certain blood cancers. Many current approaches are focused on oncology targets, leaving numerous potential applications underexplored. Targeting proteins for degradation offers a novel therapeutic route for targets whose inhibition remains challenging,...
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📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
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Incoming
1
Outgoing
1
0 supporting
0 contradicting
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