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Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitro.
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ID: paper-39487455
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Blood-brain barrier permeability increases with the differentiation of glioblastoma cells in vitro.
["Digiovanni S", "Lorenzati M", "Bianciotto O", "Godel M", "Fontana S", "Akman M", "Costamagna C", "Couraud P", "Buffo A", "Kopecka J"]
Abstract
BACKGROUND: Glioblastoma multiforme (GBM) is an aggressive tumor, difficult to treat pharmacologically because of the blood-brain barrier (BBB), which is rich in ATP-binding cassette (ABC) transporters and tight junction (TJ) proteins. The BBB is disrupted within GBM bulk, but it is competent in brain-adjacent-to-tumor areas, where eventual GBM foci can trigger tumor relapse. How GBM cells influence the permeability of BBB is poorly investigated. METHODS: To clarify this point, we co-cultured hu...
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