Targeting G3BP1-Mediated Stress Granules to Suppress SARS-CoV-2 Replication.

Stress granules (SGs) are cytoplasmic, membraneless assemblies of proteins and RNAs that transiently form in response to cellular stress. Dysregulation of SGs has been associated with cancer, neurodegeneration, and viral infection. GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a central SG component that regulates granule assembly and dynamics through protein-RNA and protein-protein interactions (PPIs). During viral infection, SGs can be hijacked to enhance viral replication ...