TFRC

Transferrin receptor protein 1

Score: 0.644 Price: $0.64 Medium Druggability Status: active Wiki: TFRC

🧠 Neurodegeneration

HYPOTHESES

PAPERS

KG EDGES

151

DEBATES

3D Protein Structure

🧬 TFRC — PDB 1CX8 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Medium

Score: 0.47

Clinical Stage

Approved

Target Class

Receptor

Safety

0.50

Druggability Analysis

Drug Development0.60

Structural Tractability0.85

Target Class0.70

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (2 compounds)

Therapeutic Areas:

Neurodegenerative diseases (Alzheimer's, Parkinson's) Iron overload disorders Neuroinflammation Ferroptosis-related pathologies Targeted drug delivery to CNS

Druggability Rationale: TFRC is highly druggable (0.80 score) due to its well-characterized receptor structure with 19 PDB entries at high resolution (1.85 Å), enabling rational design of both monoclonal antibodies and small-molecule iron chelators. The target's established mechanism of action with approved drugs (Deferasirox) and ongoing clinical-stage antibody therapies demonstrates clear validation for therapeutic intervention.

Mechanism: Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake

Drug Pipeline (2 compounds)

Known Drugs:

Deferasirox (Approved) — Iron chelation

Anti-TfR1 antibodies (Clinical trials) — Drug delivery

Structural Data:

PDB (19) ✓AlphaFold ✓Cryo-EM ✓

1SUV 2NSU 3S9L 3S9M 3S9N+14 more

UniProt: G3V0E5

Binding Pocket Analysis:

TFRC features a large extracellular binding pocket for transferrin-iron complex recognition, characterized by conserved histidine and aspartate residues coordinating iron binding; antibody epitopes target conformational regions on the ectodomain that allosterically modulate transferrin binding and receptor internalization. Cryo-EM and high-resolution crystal structures (1.85 Å) provide detailed maps of both the transferrin-binding interface and potential allosteric pockets for small-molecule modulators.

🧬 3D Protein Structure

🧬 TFRC — PDB 1CX8 Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Selectivity & Safety Considerations

TFRC selectivity is generally favorable as the transferrin receptor isoform is the primary iron uptake mechanism in most tissues; however, off-target effects on systemic iron homeostasis and potential impacts on erythropoiesis must be carefully monitored. Monoclonal antibodies offer superior selectivity compared to broad iron chelators, reducing systemic iron dysregulation.