gene

PPP1CB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPP1CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections
0Hypotheses
0Analyses
50Outgoing
37Incoming

Summary

PPP1CB is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, therapeutic target. Associated with ALS, Als, Cancer. Connected to 47 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolPPP1CB
Chromosome2p23.3
Protein FamilyProtein phosphatase type 1 family
Molecular Weight37 kDa
PathwaysEpigenetic
Ensembl IDENSG00000185630
GeneCardsPPP1CB
Human Protein AtlasPPP1CB
Associated DiseasesALS, Inflammation, Parkinson
InteractionsHK2, NSD3, STAT3, CANCER
KG Connections111 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

PPP1CB Gene

gene · 538 words

PPP1CC Gene - Protein Phosphatase 1 Catalytic Subunit Gamma

gene · 1201 words

NSD3 (Nuclear Receptor Binding SET Domain Protein 3)

gene · 1070 words

STAT3 Protein

protein · 612 words

STAT3 (Redirect)

redirect · 612 words

PP1 Protein

protein · 611 words

Pathway Diagram

graph TD
    PPP1CB["<b>PPP1CB</b>"]
    STAT3["STAT3"]
    PPP1CB -->|"modifies"| STAT3
    Als{"Als"}
    PPP1CB -->|"associated with"| Als
    Parkinson{"Parkinson"}
    PPP1CB -->|"therapeutic target"| Parkinson
    Inflammation{"Inflammation"}
    PPP1CB -->|"therapeutic target"| Inflammation
    Cancer{"Cancer"}
    PPP1CB -->|"inhibits"| Cancer
    Carcinoma{"Carcinoma"}
    PPP1CB -->|"inhibits"| Carcinoma
    ALS{"ALS"}
    PPP1CB -->|"associated with"| ALS
    PPP1CB -->|"associated with"| Parkinson
    PPP1CB -->|"associated with"| Inflammation
    TLR2["TLR2"]
    PPP1CB -->|"therapeutic target"| TLR2
    MTOR["MTOR"]
    PPP1CB -->|"associated with"| MTOR
    BID["BID"]
    PPP1CB -->|"associated with"| BID
    NSD3["NSD3"]
    NSD3 -->|"interacts with"| PPP1CB
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| PPP1CB
    TFRC["TFRC"]
    TFRC -->|"associated with"| PPP1CB
    MTOR -->|"associated with"| PPP1CB
    GENES["GENES"]
    GENES -->|"therapeutic target"| PPP1CB
    BID -->|"associated with"| PPP1CB
    BAD["BAD"]
    BAD -->|"associated with"| PPP1CB
    TLR2 -->|"therapeutic target"| PPP1CB
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| PPP1CB
    IFN["IFN"]
    IFN -->|"associated with"| PPP1CB
    GENES -->|"associated with"| PPP1CB
    style PPP1CB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (74)

TargetRelationTypeStr
STAT3modifiesprotein0.90
Antimicrobial Responsesinvolved_inprocess0.80
Antimicrobial Responseinvolved_inprocess0.80
antimicrobial peptide activityinvolved_inprocess0.75
Alsassociated_withdisease0.65

Incoming (37)

SourceRelationTypeStr
NSD3interacts_withprotein0.90
LAMP2associated_withgene0.60
TFRCassociated_withgene0.60
MTORassociated_withgene0.60
BIDassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found