Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPP1CB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PPP1CB is a gene implicated in neurodegeneration research. Key relationships include: associated with, inhibits, therapeutic target. Associated with ALS, Als, Cancer. Connected to 47 entities in the SciDEX knowledge graph.
| Gene Symbol | PPP1CB |
| Chromosome | 2p23.3 |
| Protein Family | Protein phosphatase type 1 family |
| Molecular Weight | 37 kDa |
| Pathways | Epigenetic |
| Ensembl ID | ENSG00000185630 |
| GeneCards | PPP1CB |
| Human Protein Atlas | PPP1CB |
| Associated Diseases | ALS, Inflammation, Parkinson |
| Interactions | HK2, NSD3, STAT3, CANCER |
| KG Connections | 111 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PPP1CB["<b>PPP1CB</b>"]
STAT3["STAT3"]
PPP1CB -->|"modifies"| STAT3
Als{"Als"}
PPP1CB -->|"associated with"| Als
Parkinson{"Parkinson"}
PPP1CB -->|"therapeutic target"| Parkinson
Inflammation{"Inflammation"}
PPP1CB -->|"therapeutic target"| Inflammation
Cancer{"Cancer"}
PPP1CB -->|"inhibits"| Cancer
Carcinoma{"Carcinoma"}
PPP1CB -->|"inhibits"| Carcinoma
ALS{"ALS"}
PPP1CB -->|"associated with"| ALS
PPP1CB -->|"associated with"| Parkinson
PPP1CB -->|"associated with"| Inflammation
TLR2["TLR2"]
PPP1CB -->|"therapeutic target"| TLR2
MTOR["MTOR"]
PPP1CB -->|"associated with"| MTOR
BID["BID"]
PPP1CB -->|"associated with"| BID
NSD3["NSD3"]
NSD3 -->|"interacts with"| PPP1CB
LAMP2["LAMP2"]
LAMP2 -->|"associated with"| PPP1CB
TFRC["TFRC"]
TFRC -->|"associated with"| PPP1CB
MTOR -->|"associated with"| PPP1CB
GENES["GENES"]
GENES -->|"therapeutic target"| PPP1CB
BID -->|"associated with"| PPP1CB
BAD["BAD"]
BAD -->|"associated with"| PPP1CB
TLR2 -->|"therapeutic target"| PPP1CB
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"associated with"| PPP1CB
IFN["IFN"]
IFN -->|"associated with"| PPP1CB
GENES -->|"associated with"| PPP1CB
style PPP1CB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| STAT3 | modifies | protein | 0.90 |
| Antimicrobial Responses | involved_in | process | 0.80 |
| Antimicrobial Response | involved_in | process | 0.80 |
| antimicrobial peptide activity | involved_in | process | 0.75 |
| Als | associated_with | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Cancer | inhibits | disease | 0.65 |
| Carcinoma | inhibits | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Ferroptosis | expressed_in | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| TLR2 | therapeutic_target | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| BID | associated_with | gene | 0.60 |
| BAD | associated_with | gene | 0.60 |
| TFRC | associated_with | gene | 0.60 |
| HK2 | inhibits | gene | 0.60 |
| NSD3 | inhibits | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| TLR2 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| TFRC | degrades | entity | 0.60 |
| MTOR | expressed_in | gene | 0.60 |
| Il-17 | therapeutic_target | protein | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| ferroptosis | associated_with | process | 0.60 |
| SMAD4 | expressed_in | gene | 0.60 |
| Ferroptosis | associated_with | pathway | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Immune Response | therapeutic_target | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| Epigenetic | regulates | pathway | 0.60 |
| Glycolysis | inhibits | pathway | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| FERROPTOSIS | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| Immune Response | associated_with | pathway | 0.60 |
| GENES | associated_with | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| IFN | associated_with | gene | 0.60 |
| IFN-Γ | therapeutic_target | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| IFN | therapeutic_target | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NSD3 | interacts_with | protein | 0.90 |
| LAMP2 | associated_with | gene | 0.60 |
| TFRC | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| BID | associated_with | gene | 0.60 |
| BAD | associated_with | gene | 0.60 |
| TLR2 | therapeutic_target | gene | 0.60 |
| BAD | degrades | entity | 0.60 |
| BID | degrades | entity | 0.60 |
| LAMP2 | degrades | entity | 0.60 |
| MTOR | degrades | entity | 0.60 |
| BID | expressed_in | gene | 0.60 |
| BMPR1A | expressed_in | gene | 0.60 |
| GENES | therapeutic_target | gene | 0.60 |
| APOPTOSIS | associated_with | gene | 0.60 |
| IFN | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PSME3 | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| IL-1 | therapeutic_target | gene | 0.60 |
| IL-17 | therapeutic_target | gene | 0.60 |
| FERROPTOSIS | associated_with | gene | 0.60 |
| IL-17 | associated_with | gene | 0.60 |
| BAD | co_discussed | gene | 0.50 |
| BID | co_discussed | gene | 0.50 |
| LAMP2 | co_discussed | protein | 0.50 |
| MTOR | co_discussed | gene | 0.50 |
| PARKIN | co_discussed | gene | 0.50 |
| AUTOPHAGY | co_discussed | gene | 0.50 |
| GENES | co_discussed | gene | 0.50 |
| IFN-Γ | co_discussed | protein | 0.50 |
| IL-1Β | co_discussed | protein | 0.50 |
| PARKINSON | co_discussed | gene | 0.50 |
| Autophagy | expressed_in | process | 0.50 |
| mTOR | expressed_in | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||