concept

ALOX5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALOX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

234Connections
1Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

ALOX5 is a concept in neurodegeneration research. Key relationships include: activates, contributes to, co discussed. Associated with ALS, Allergic Rhinitis, Als. Connected to 69 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info
NameALOX5
Key Genes/ProteinsALOX15
Related DiseasesOsteoarthritis, asthma, Multiple Sclerosis, Epilepsy
Related PathwaysNF-kB Signaling
🧬 3D Structure: ALOX5 — PDB 3O8Y Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (19)

Knowledge base pages for this entity

neuroinflammation

mechanism · 5462 words

Ferroptosis in Neurodegeneration

mechanism · 3536 words

Neuroinflammation Pathway

mechanisms · 3067 words

Dopamine Agonists

therapeutic · 2542 words

Neuroinflammation in PD

mechanism · 2049 words

Pathway Diagram

graph TD
    ALOX5["ALOX5"]
    ALOX5 -->|"interacts"| Als["Als"]
    ALOX5 -->|"activates"| Cancer["Cancer"]
    ALOX5 -->|"contributes to"| Multiple_Sclerosis["Multiple Sclerosis"]
    ALOX5 -->|"regulates"| Inflammation["Inflammation"]
    ALOX5 -->|"contributes to"| Epilepsy["Epilepsy"]
    ALOX5 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    ALOX5 -->|"contributes to"| Alzheimer["Alzheimer"]
    ALOX5 -->|"contributes to"| Parkinson["Parkinson"]
    ALOX5 -->|"activates"| Fibrosis["Fibrosis"]
    h_13bbfdc5["h-13bbfdc5"] -->|"targets"| ALOX5
    ALOX12["ALOX12"] -->|"co_expressed_with"| ALOX5
    GENES["GENES"] -->|"contributes to"| ALOX5
    HMOX1["HMOX1"] -->|"activates"| ALOX5
    ALOX["ALOX"] -->|"contributes to"| ALOX5
    ALOX15["ALOX15"] -->|"contributes to"| ALOX5
    HK2["HK2"] -->|"activates"| ALOX5

Outgoing (153)

TargetRelationTypeStr
arachidonic acidassociated_withcompound0.95
Lipoxygenasesassociated_withenzyme0.90
Osteoarthritisassociated_withdisease0.88
NF-kB Signalingregulatespathway0.85
ALOX15associated_withgene0.85

Incoming (81)

SourceRelationTypeStr
Perillaldehydedownregulatescompound0.90
h-13bbfdc5targets_genehypothesis0.90
SBFI26upregulatesdrug0.85
h-13bbfdc5targetshypothesis0.80
ALOX12co_expressed_withgene0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Mitochondrial SPM Synthesis Platform Engineering 0.383 neurodegeneration Neuroinflammation resolution mechanisms

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] Yang J, Borchert A, Kuhn H J Biol Chem 2026 1
SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] He G, Zhang Y, Feng Y, Chen T, Liu M, Ze J Cell Mol Med 2024 1
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] Li C, Zhang Y, Liu J, Kang R, Klionsky D Autophagy 2021 1
5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential th [PMID:32222525] Chen F, Ghosh A, Lin J, Zhang C, Pan Y, Brain Behav Immun 2020 1
Decoding cell death signals in liver inflammation. [PMID:23567086] Brenner C, Galluzzi L, Kepp O, Kroemer G J Hepatol 2013 1
Arachidonate lipoxygenase 5 metabolism axis promoting ferroptosis: a potential d [PMID:41942611] Chen L, Sun X, Zhang H, Zhang X, Muhetar Br J Cancer 2026 0
Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to i [PMID:40773543] Bachtel ND, Cullen JL, Liu M, Erickson S Science (New York, N.Y.) 2025 0
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulti [PMID:35288557] Günes Günsel G, Conlon TM, Jeridi A, Kim Nature communications 2022 0
Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633] ["Corces M", "Shcherbina A", "Kundu S", Nature genetics 2020 0
Factors associated with the number of drugs in darunavir/cobicistat regimens. [PMID:31586414] ["Martinez E", "Negredo E", "Knobel H", The Journal of antimicrobial c 2020 0
The influence of muscle length on gastrocnemius and vastus lateralis muscle oxyg [PMID:31563842] ["Williamson S", "Sanni A", "McCully K"] Journal of electromyography an 2019 0
Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reac [PMID:30291143] ["Liou G", "Chiang Y", "Wang Y", "Weng J The Journal of biological chem 2018 0
Prevalence and risk factors of excessive daytime sleepiness in insomnia sufferer [PMID:29167048] ["Hein M", "Lanquart J", "Loas G", "Huba Journal of psychosomatic resea 2017 0
The association of insertions/deletions (INDELs) and variable number tandem repe [PMID:28615046] ["Say Y"] Journal of physiological anthr 2017 0
Diversity of bats trypanosomes in hydroeletric area of Belo Monte in Brazilian A [PMID:27633579] ["da Costa A", "Nunes P", "Leite B", "Fe Acta tropica 2016 0
Towards quantitative electrostatic potential mapping of working semiconductor de [PMID:25576656] ["Yazdi S", "Kasama T", "Beleggia M", "S Ultramicroscopy 2015 0
Unusual CD8 positive lymphomatoid papulosis in childhood. [PMID:25419749] Mateo S, Vázquez Osorio I, José Seoane M Dermatology online journal 2014 0
Application of a scattered-light radiometric power meter. [PMID:21528989] ["Caron J", "DiComo G", "Ting A", "Fisch The Review of scientific instr 2011 0