Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ALOX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ALOX5 is a concept in neurodegeneration research. Key relationships include: activates, contributes to, co discussed. Associated with ALS, Allergic Rhinitis, Als. Connected to 69 entities in the SciDEX knowledge graph.
| Name | ALOX5 |
| Key Genes/Proteins | ALOX15 |
| Related Diseases | Osteoarthritis, asthma, Multiple Sclerosis, Epilepsy |
| Related Pathways | NF-kB Signaling |
Knowledge base pages for this entity
graph TD
ALOX5["ALOX5"]
ALOX5 -->|"interacts"| Als["Als"]
ALOX5 -->|"activates"| Cancer["Cancer"]
ALOX5 -->|"contributes to"| Multiple_Sclerosis["Multiple Sclerosis"]
ALOX5 -->|"regulates"| Inflammation["Inflammation"]
ALOX5 -->|"contributes to"| Epilepsy["Epilepsy"]
ALOX5 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
ALOX5 -->|"contributes to"| Alzheimer["Alzheimer"]
ALOX5 -->|"contributes to"| Parkinson["Parkinson"]
ALOX5 -->|"activates"| Fibrosis["Fibrosis"]
h_13bbfdc5["h-13bbfdc5"] -->|"targets"| ALOX5
ALOX12["ALOX12"] -->|"co_expressed_with"| ALOX5
GENES["GENES"] -->|"contributes to"| ALOX5
HMOX1["HMOX1"] -->|"activates"| ALOX5
ALOX["ALOX"] -->|"contributes to"| ALOX5
ALOX15["ALOX15"] -->|"contributes to"| ALOX5
HK2["HK2"] -->|"activates"| ALOX5| Target | Relation | Type | Str |
|---|---|---|---|
| arachidonic acid | associated_with | compound | 0.95 |
| Lipoxygenases | associated_with | enzyme | 0.90 |
| Osteoarthritis | associated_with | disease | 0.88 |
| NF-kB Signaling | regulates | pathway | 0.85 |
| ALOX15 | associated_with | gene | 0.85 |
| lipoxygenase | associated_with | enzyme | 0.80 |
| asthma | involved_in | disease | 0.80 |
| ferroptosis | promotes | process | 0.80 |
| Multiple Sclerosis | involved_in | disease | 0.75 |
| Epilepsy | involved_in | disease | 0.75 |
| Ferroptosis | involved_in | process | 0.75 |
| ferroptosis | participates_in | pathway | 0.70 |
| Als | interacts_with | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Multiple Sclerosis | contributes_to | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Epilepsy | contributes_to | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Alzheimer | contributes_to | disease | 0.65 |
| Parkinson | contributes_to | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Parkinson | protects_against | disease | 0.65 |
| Ferroptosis | therapeutic_target | disease | 0.65 |
| Ferroptosis | regulates | disease | 0.65 |
| Stroke | therapeutic_target | disease | 0.65 |
| ALOX12 | contributes_to | gene | 0.60 |
| ALOX15 | contributes_to | gene | 0.60 |
| HMOX1 | activates | gene | 0.60 |
| ALOX15 | activates | gene | 0.60 |
| ALOX12 | activates | gene | 0.60 |
| NFE2L2 | activates | gene | 0.60 |
| FER | activates | gene | 0.60 |
| ACSL4 | activates | gene | 0.60 |
| neurodegeneration | implicated_in | disease | 0.60 |
| PKC | interacts_with | gene | 0.60 |
| CD8 | therapeutic_target | gene | 0.60 |
| PTGS2 | regulates | gene | 0.60 |
| HIF1A | regulates | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| neuroinflammation | regulates | disease | 0.60 |
| epilepsy | implicated_in | disease | 0.60 |
| ferroptosis | activates | process | 0.60 |
| ferroptosis | protects_against | process | 0.60 |
| ferroptosis | inhibits | pathway | 0.60 |
| NFE2L2 | inhibits | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Perillaldehyde | downregulates | compound | 0.90 |
| h-13bbfdc5 | targets_gene | hypothesis | 0.90 |
| SBFI26 | upregulates | drug | 0.85 |
| h-13bbfdc5 | targets | hypothesis | 0.80 |
| ALOX12 | co_expressed_with | gene | 0.65 |
| ALOX12 | contributes_to | gene | 0.60 |
| HMOX1 | activates | gene | 0.60 |
| ALOX12 | activates | gene | 0.60 |
| ALOX15 | contributes_to | gene | 0.60 |
| ALOX15 | activates | gene | 0.60 |
| HK2 | activates | gene | 0.60 |
| FER | activates | gene | 0.60 |
| NFE2L2 | activates | gene | 0.60 |
| ALOX12 | associated_with | entity | 0.60 |
| ALOX15 | associated_with | entity | 0.60 |
| STAT3 | regulates | gene | 0.60 |
| PKC | interacts_with | gene | 0.60 |
| ALOX12 | implicated_in | gene | 0.60 |
| ALOX15 | implicated_in | gene | 0.60 |
| ALOX15 | inhibits | gene | 0.60 |
| ALOX15 | expressed_in | gene | 0.60 |
| GENES | contributes_to | gene | 0.60 |
| ALOX | contributes_to | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| ALZHEIMER | contributes_to | gene | 0.60 |
| EPILEPSY | contributes_to | gene | 0.60 |
| ALOX12B | contributes_to | gene | 0.60 |
| ALOX15B | contributes_to | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| ALOXE3 | contributes_to | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ALOXE3 | activates | gene | 0.60 |
| GSH | activates | gene | 0.60 |
| NEUROINFLAMMATION | regulates | gene | 0.60 |
| PARKINSON | contributes_to | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| PARKINSON'S DISEASE | contributes_to | gene | 0.60 |
| PARKINSON | protects_against | gene | 0.60 |
| NEURON | inhibits | gene | 0.60 |
| FERROPTOSIS | protects_against | gene | 0.60 |
| PARKINSON'S DISEASE | protects_against | gene | 0.60 |
| STROKE | therapeutic_target | gene | 0.60 |
| CHAC1 | activates | gene | 0.60 |
| SAT1 | activates | gene | 0.60 |
| ALOX | implicated_in | gene | 0.60 |
| ALOX12B | implicated_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial SPM Synthesis Platform Engineering | 0.383 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death. [PMID:32186434] | Li C, Zhang Y, Liu J, Kang R, Klionsky D | Autophagy | 2021 | 1 |
| 5-lipoxygenase pathway and its downstream cysteinyl leukotrienes as potential th [PMID:32222525] | Chen F, Ghosh A, Lin J, Zhang C, Pan Y, | Brain Behav Immun | 2020 | 1 |
| Decoding cell death signals in liver inflammation. [PMID:23567086] | Brenner C, Galluzzi L, Kepp O, Kroemer G | J Hepatol | 2013 | 1 |
| Arachidonate lipoxygenase 5 metabolism axis promoting ferroptosis: a potential d [PMID:41942611] | Chen L, Sun X, Zhang H, Zhang X, Muhetar | Br J Cancer | 2026 | 0 |
| Intestinal mast cell-derived leukotrienes mediate the anaphylactic response to i [PMID:40773543] | Bachtel ND, Cullen JL, Liu M, Erickson S | Science (New York, N.Y.) | 2025 | 0 |
| The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulti [PMID:35288557] | Günes Günsel G, Conlon TM, Jeridi A, Kim | Nature communications | 2022 | 0 |
| Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633] | ["Corces M", "Shcherbina A", "Kundu S", | Nature genetics | 2020 | 0 |
| Factors associated with the number of drugs in darunavir/cobicistat regimens. [PMID:31586414] | ["Martinez E", "Negredo E", "Knobel H", | The Journal of antimicrobial c | 2020 | 0 |
| The influence of muscle length on gastrocnemius and vastus lateralis muscle oxyg [PMID:31563842] | ["Williamson S", "Sanni A", "McCully K"] | Journal of electromyography an | 2019 | 0 |
| Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reac [PMID:30291143] | ["Liou G", "Chiang Y", "Wang Y", "Weng J | The Journal of biological chem | 2018 | 0 |
| Prevalence and risk factors of excessive daytime sleepiness in insomnia sufferer [PMID:29167048] | ["Hein M", "Lanquart J", "Loas G", "Huba | Journal of psychosomatic resea | 2017 | 0 |
| The association of insertions/deletions (INDELs) and variable number tandem repe [PMID:28615046] | ["Say Y"] | Journal of physiological anthr | 2017 | 0 |
| Diversity of bats trypanosomes in hydroeletric area of Belo Monte in Brazilian A [PMID:27633579] | ["da Costa A", "Nunes P", "Leite B", "Fe | Acta tropica | 2016 | 0 |
| Towards quantitative electrostatic potential mapping of working semiconductor de [PMID:25576656] | ["Yazdi S", "Kasama T", "Beleggia M", "S | Ultramicroscopy | 2015 | 0 |
| Unusual CD8 positive lymphomatoid papulosis in childhood. [PMID:25419749] | Mateo S, Vázquez Osorio I, José Seoane M | Dermatology online journal | 2014 | 0 |
| Application of a scattered-light radiometric power meter. [PMID:21528989] | ["Caron J", "DiComo G", "Ting A", "Fisch | The Review of scientific instr | 2011 | 0 |