concept

CMKLR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CMKLR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

235Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CMKLR1 is a concept in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with ALS, Aging, Als. Connected to 84 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CMKLR1
Key Genes/Proteins	IL33, GPR32
Related Diseases	pro-inflammatory state, male hypogonadism
Related Pathways	glycolysis, type 2 innate immunity

🔮 Predicted Structure: CMKLR1 — AlphaFold F8VYN7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CMKLR1["CMKLR1"]
    CMKLR1 -->|"activates"| Cancer["Cancer"]
    CMKLR1 -->|"activates"| Aging["Aging"]
    CMKLR1 -->|"activates"| Obesity["Obesity"]
    CMKLR1 -->|"activates"| Ischemia["Ischemia"]
    CMKLR1 -->|"activates"| Ms["Ms"]
    CMKLR1 -->|"interacts"| Alzheimer["Alzheimer"]
    CMKLR1 -->|"interacts"| Als["Als"]
    Chemerin["Chemerin"] -->|"binds"| CMKLR1
    h_470ff83e["h-470ff83e"] -->|"targets"| CMKLR1
    CD47["CD47"] -->|"interacts"| CMKLR1
    TLR2["TLR2"] -->|"interacts"| CMKLR1
    CD36["CD36"] -->|"interacts"| CMKLR1
    PINK1["PINK1"] -->|"activates"| CMKLR1
    PARKIN["PARKIN"] -->|"activates"| CMKLR1
    RAGE["RAGE"] -->|"activates"| CMKLR1
    CD14["CD14"] -->|"interacts"| CMKLR1

Outgoing (157)

Target	Relation	Type	Str
testicular macrophages	modulates	cell_type	0.95
thermogenesis	inhibits	process	0.90
glycolysis	mediates	pathway	0.90
pro-inflammatory state	promotes	phenotype	0.90
immunometabolism	modulates	process	0.90
autophagy	modulates	process	0.85
IL33	regulates	gene	0.85
type 2 innate immunity	suppresses	pathway	0.85
male hypogonadism	therapeutic_target	disease	0.80
MICROGLIA	interacts_with	cell_type	0.80
GPR32	encodes	protein	0.80
microglia	activates	cell_type	0.70
microglia	regulates	cell_type	0.70
Cancer	activates	disease	0.65
Aging	activates	disease	0.65
Obesity	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Aging	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
ALS	interacts_with	disease	0.65
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
RAGE	activates	gene	0.60
TLR4	interacts_with	gene	0.60
CD14	interacts_with	gene	0.60
P62	activates	gene	0.60
TLR2	interacts_with	gene	0.60
TLR2	regulates	gene	0.60
TLR4	regulates	gene	0.60
neurodegeneration	implicated_in	disease	0.60
CD36	interacts_with	gene	0.60
CD47	interacts_with	gene	0.60
P62	regulates	entity	0.60
PARKIN	regulates	entity	0.60
PINK1	regulates	entity	0.60
Rb	activates	protein	0.60
Rb	interacts_with	protein	0.60
obesity	activates	disease	0.60
obesity	inhibits	disease	0.60
obesity	regulates	disease	0.60
obesity	treats	disease	0.60
mitochondrial dynamics	participates_in	pathway	0.60
RAGE	regulates	gene	0.60
GPR109A	associated_with	gene	0.60
purinergic receptor	associated_with	receptor	0.60

Incoming (78)

Source	Relation	Type	Str
P12C5	targets	drug	0.95
CD206LoMHCIIHi macrophage subset	expressed_in	cell_type	0.90
h-470ff83e	targets_gene	hypothesis	0.90
h-470ff83e	targets	hypothesis	0.80
CD47	interacts_with	gene	0.60
TLR2	interacts_with	gene	0.60
CD36	interacts_with	gene	0.60
PINK1	activates	gene	0.60
PARKIN	activates	gene	0.60
RAGE	activates	gene	0.60
CD14	interacts_with	gene	0.60
CD14	regulates	gene	0.60
CD36	regulates	gene	0.60
CD47	regulates	gene	0.60
P62	activates	gene	0.60
TLR4	interacts_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
PHAGOCYTOSIS	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
AGING	activates	gene	0.60
PAD4	activates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
IL-33	activates	gene	0.60
AND	regulates	gene	0.60
CANCER	activates	gene	0.60
OBESITY	activates	disease	0.50
OBESITY	regulates	disease	0.50
microglia	activates	cell_type	0.50
Autophagy	activates	process	0.50
oxidative stress	activates	phenotype	0.50
NEURONS	activates	concept	0.50
microglia	regulates	cell_type	0.50
Autophagy	regulates	process	0.50
oxidative stress	regulates	phenotype	0.50
Mitochondrial Function	regulates	pathway	0.50
microglia	expressed_in	cell_type	0.50
Autophagy	expressed_in	process	0.50
apoptosis	expressed_in	process	0.50
oxidative stress	expressed_in	phenotype	0.50
mitophagy	activates	pathway	0.50
microglia	inhibits	cell_type	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial Efferocytosis Enhancement via GPR32 Superagonists	0.483	neurodegeneration	Neuroinflammation resolution mechanisms

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552

Related Papers (19)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in dia [PMID:41054305]	Xiong Y, Li R, Chen X, Peng C, Zeng Q, Z	Mol Ther	2026	1
Chemerin-CMKLR1 differentially mediated OGD/R-induced mitochondrial dysfunction, [PMID:41151300]	Long PY, Tang Z, Cai N, Yan ZQ, Gao X, W	Biomed Pharmacother	2025	1
The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/I [PMID:34330814]	Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B,	Sci Immunol	2021	1
Microglial Aβ receptors in Alzheimer's disease. [PMID:25149075]	Yu Y, Ye RD	Cell Mol Neurobiol	2015	1
Molecular Signaling and Biased Agonism of the CHEMR23 Receptor: Implications for [PMID:41486998]	["Neprelyuk O", "Romanenko I", "Irza O",	Current protein & peptide scie	2026	0
Receptor-Mediated Shuttling of a D-Amino Acid Peptide Achieves High Nanomolar Cy [PMID:41422545]	["List M", "Beck-Sickinger A"]	Journal of the American Chemic	2026	0
Follicle-dependent differential localization of adipokines in the letrozole-indu [PMID:41857436]	["Dutta A", "Gurusubramanian G", "Roy V"	Histochemistry and cell biolog	2026	0
Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Mid [PMID:41538650]	["Zhu Z", "Du F", "Liu Y", "Yang J", "Ge	Advanced science (Weinheim, Ba	2026	0
Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary a [PMID:36600187]	["Sanges S", "Rice L", "Tu L", "Valenzi	Annals of the rheumatic diseas	2023	0
The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Depos [PMID:36012305]	Chen Y, Liu Z, Gong P, Zhang H, Chen Y,	International journal of molec	2022	0
Chemerin partly mediates tumor-inhibitory effect of all-trans retinoic acid via [PMID:31063220]	Song Y, Yin W, Dan Y, Sheng J, Zeng Y, H	Immunology	2019	0
Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in d [PMID:30784180]	["Shang J", "Wang L", "Zhang Y", "Zhang	Journal of cellular and molecu	2019	0
Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri [PMID:27860453]	["Huang J", "Burston J", "Li L", "Ashraf	Arthritis & rheumatology (Hobo	2017	0
Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, pa [PMID:25713056]	["Patrick R", "Ames B"]	FASEB journal : official publi	2015	0
The chemerin receptor CMKLR1 is a functional receptor for amyloid-β peptide. [PMID:25079809]	Peng L, Yu Y, Liu J, Li S, He H, Cheng N	Journal of Alzheimer's disease	2015	0
Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in r [PMID:24622516]	["Spencer A", "Labonte E", "Rosenbaum D"	Science translational medicine	2014	0
Overexpression of Ras homologous C (RhoC) induces malignant transformation of he [PMID:23382905]	["Xie S", "Zhu M", "Lv G", "Geng Y", "Ch	PloS one	2013	0
International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coup [PMID:23686350]	["Davenport A", "Alexander S", "Sharman	Pharmacological reviews	2013	0
Resolvins: natural agonists for resolution of pulmonary inflammation. [PMID:20887750]	Uddin M, Levy BD	Progress in lipid research	2011	0

CMKLR1

Understanding Entity Pages

Summary

Wiki Pages (10)

neuroinflammation

TREM2 Signaling in Neurodegeneration

Neuroinflammation Pathway

Section 244: Advanced Autophagy Induction and TFEB Activation in CBS/PSP

Mitochondrial Dynamics

Neuroinflammation in PD

Neuroinflammation in Corticobasal Degeneration

Neuroinflammation in Corticobasal Syndrome

Neuroinflammation and Microglia Pathway in Alzheimer's Disease