Contents

TFRC

🧬 Gene Info

Gene Symbol	TFRC
Full Name	Transferrin Receptor 1
Aliases	CD71, TFR1
Chromosome	3q29
Protein Type	Receptor
Target Class	Receptor
Function	Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake
Mechanism of Action	Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake
Druggability	Medium (0.47)
Clinical Stage	Approved
Molecular Weight	190 kDa
Amino Acids	660 aa
Pathways	Akt, Autophagy, Blood-Brain Barrier, Ferroptosis, Pi3K
UniProt ID	P02786
NCBI Gene ID	7037
Ensembl ID	ENSG00000072274
GeneCards	TFRC
Human Protein Atlas	TFRC
Associated Diseases	ALS, ALZHEIMER, Atherosclerosis, Diabetes, Inflammation
Known Drugs/Compounds	Antisense Oligonucleotides, Adeno-Associated Virus, resveratrol, rapamycin
Interactions	SLC7A11, P38, GPX4, ACSL4, GCLC, JUN
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Blood-Brain Barrier SPM Shuttle System
KG Connections	380 knowledge graph edges
Databases	GeneCards HPA STRING

Knowledge Graph