| Gene Symbol | PVALB |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | No known druggable mechanism |
| Mechanism of Action | No known druggable mechanism |
| Primary Expression | a specific subset of GABAergic interneurons known as fast-spiking parvalbumin-positive (PV+) interneurons, which play critical roles in regulating cor |
| Druggability | Low (0.34) |
| Clinical Stage | Phase II |
| Molecular Weight | 12 kDa |
| Amino Acids | 109 aa |
| Pathways | Autophagy, Epigenetic, GABAergic signaling, Thalamo-Amygdala Signaling, Wnt |
| UniProt ID | P20472 |
| Ensembl ID | ENSG00000100347 |
| GeneCards | PVALB |
| Human Protein Atlas | PVALB |
| Associated Diseases | ALS, AUTISM, Aging, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | 17-β estradiol |
| Interactions | NR3C1, FKBP5, TAU, SST, PENK, TRKB |
| SciDEX Target | View Target Profile (3 clinical trials) |
| SciDEX Hypotheses | Closed-loop transcranial focused ultrasound to res Closed-loop transcranial focused ultrasound with 4 Closed-loop tACS targeting EC-II PV interneurons t (+10 more) |
| KG Connections | 637 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |