gene 2,283 words KG: CASP3
Contents

CASP3 Gene

🧬 Gene Info
Gene SymbolCASP3
Full NameCaspase 3
Chromosome4q34
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight20 kDa
Amino Acids277 aa
PathwaysAkt, Apoptosis, Autophagy, Epigenetic, Glycolysis
UniProt ID[P42574](https://www.uniprot.org/uniprot/P42574)
Ensembl IDENSG00000164305
GeneCardsCASP3
Human Protein AtlasCASP3
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Alzheimer_disease
Known Drugs/CompoundsRAPAMYCIN, RESVERATROL, SPERMIDINE, aristolochic_acids, herbicides, R-PE
InteractionsSQSTM1, RPS6KB1, GRB2, RHEB, STING1, EIF2A
KG Connections1507 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (27)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
TREM2-mediated microglial tau clearance enhancement
Score: 0.80
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78

Related Analyses (7)

Senescent cell clearance as neurodegeneration therapy
neurodegeneration · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived

See Also (5)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in
AIM2 Inflammasome Modulation Therapy for Neurodegenerat
idea · KG edge: associated_with
AKT1 Gene
gene · KG edge: inhibits
ACTB Gene
gene · KG edge: associated_with
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

CASP3 activates CFTR
CASP3 activates JNK
CASP3 involved_in APOPTOSIS
CASP3 provides_data_for ds-db4a006ea647
CASP3 encodes CASPASE3
CASP3 regulates AKT1
CASP3 regulates CALCOCO2
CASP3 regulates CGAS
CASP3 regulates CFTR
CASP3 interacts_with SQSTM1

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