concept

AMYGDALA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYGDALA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

249Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AMYGDALA
Summary	Comprehensive overview of the amygdala's role in emotion processing, memory consolidation, and neurodegenerative diseases including Alzheimer's and Parkinson's
Key Genes/Proteins	APP, TDP-43, AMYLOID
Related Diseases	ANXIETY, TUMOR

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AMYGDALA["AMYGDALA"]
    AMYGDALA -->|"regulates"| CORTEX["CORTEX"]
    AMYGDALA -->|"expressed in"| HIPPOCAMPUS["HIPPOCAMPUS"]
    AMYGDALA -->|"reduces"| FRONTAL["FRONTAL"]
    AMYGDALA -->|"activates"| ANXIETY["ANXIETY"]
    AMYGDALA -->|"activates"| NEURON["NEURON"]
    AMYGDALA -->|"activates"| NEURONS["NEURONS"]
    AMYGDALA -->|"activates"| TUMOR["TUMOR"]
    CRH["CRH"] -->|"expressed in"| AMYGDALA
    CRHR1["CRHR1"] -->|"expressed in"| AMYGDALA
    FKBP5["FKBP5"] -->|"expressed in"| AMYGDALA
    RAMP1["RAMP1"] -->|"expressed in"| AMYGDALA
    GENES["GENES"] -->|"expressed in"| AMYGDALA
    NR3C1["NR3C1"] -->|"expressed in"| AMYGDALA
    CALCA["CALCA"] -->|"expressed in"| AMYGDALA
    IL18["IL18"] -->|"expressed in"| AMYGDALA

Outgoing (70)

Target	Relation	Type	Str
CORTEX	regulates	brain_region	0.80
HIPPOCAMPUS	expressed_in	brain_region	0.80
CORTEX	expressed_in	brain_region	0.80
FRONTAL	reduces	brain_region	0.65
NEURONS	produces	cell_type	0.65
TDP-43	interacts_with	gene	0.65
AMYLOID	interacts_with	protein	0.65
ANXIETY	activates	disease	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
TUMOR	activates	disease	0.60
NEURON	inhibits	cell_type	0.60
FRONTAL	regulates	brain_region	0.60
PREFRONTAL	regulates	brain_region	0.60
BDNF	biomarker_for	gene	0.60
CORTEX	contributes_to	brain_region	0.60
DEPRESSION	contributes_to	disease	0.60
CORTEX	causes	brain_region	0.60
STING	targets	gene	0.60
DEPRESSION	implicated_in	disease	0.55
CORTEX	co_discussed	entity	0.50
CORTEX	activates	brain_region	0.50
ANXIETY	regulates	disease	0.50
TH	associated_with	gene	0.50
AMYLOID	associated_with	protein	0.50
AKT	associated_with	gene	0.50
TAU	associated_with	protein	0.50
NEURONS	associated_with	cell_type	0.45
NEURON	associated_with	cell_type	0.45
GABA	associated_with	phenotype	0.45
CR1	associated_with	gene	0.45
DLG4	associated_with	gene	0.45
TDP-43	associated_with	gene	0.45
APOE	associated_with	gene	0.45
TREM2	associated_with	gene	0.45
GRN	associated_with	gene	0.45
NEURON	co_discussed	cell_type	0.40
NEURONS	co_discussed	cell_type	0.40
DENTATE GYRUS	co_discussed	brain_region	0.40
FRONTAL	co_discussed	brain_region	0.40
PREFRONTAL	co_discussed	brain_region	0.40
PTSD	co_discussed	disease	0.40
HIPPOCAMPUS	co_discussed	brain_region	0.40
APP	co_discussed	gene	0.40
CR1	co_discussed	gene	0.40
HYPOTHALAMUS	co_discussed	brain_region	0.40
MICROGLIA	co_discussed	cell_type	0.40
THALAMUS	co_discussed	brain_region	0.40
STRIATUM	co_discussed	brain_region	0.40
PARIETAL	co_discussed	brain_region	0.40

Incoming (179)

Source	Relation	Type	Str
APP	associated_with	gene	0.66
TEMPORAL LOBE	interacts_with	brain_region	0.65
BDNF	associated_with	gene	0.56
TNF	associated_with	gene	0.56
ALZHEIMER'S DISEASE	associated_with	disease	0.56
DLG4	depleted_in	gene	0.55
AKT	depleted_in	gene	0.55
ASTROCYTES	implicated_in	cell_type	0.55
NEURONS	inhibits	concept	0.50
Cortex	regulates	brain_region	0.50
Cortex	activates	brain_region	0.50
Proteins	associated_with	protein	0.50
Proteins	activates	protein	0.50
TUMOR	activates	disease	0.50
ANXIETY	activates	gene	0.50
NEURONS	activates	concept	0.50
ANXIETY	interacts_with	gene	0.50
Cortex	interacts_with	brain_region	0.50
Pain	interacts_with	disease	0.50
Pain	inhibits	disease	0.50
Neuron	activates	cell_type	0.50
ptsd	associated_with	disease	0.50
Cortex	associated_with	brain_region	0.50
PREFRONTAL CORTEX	associated_with	concept	0.50
NUCLEUS	associated_with	concept	0.50
Hippocampus	activates	entity	0.50
FRONTAL	activates	concept	0.50
PREFRONTAL CORTEX	regulates	concept	0.50
ANXIETY	regulates	gene	0.50
NEURONS	regulates	concept	0.50
DEPRESSION	activates	disease	0.50
DEPRESSION	inhibits	disease	0.50
GABA	inhibits	gene	0.50
Cortex	inhibits	brain_region	0.50
Cortex	expressed_in	brain_region	0.50
GENE EXPRESSION	expressed_in	concept	0.50
DOPAMINE	associated_with	concept	0.50
DOPAMINE	activates	concept	0.50
HCRT	activates	concept	0.50
microglia	expressed_in	cell_type	0.50
ALZHEIMER	expressed_in	gene	0.50
aging	expressed_in	phenotype	0.50
Alzheimer'S Disease	expressed_in	disease	0.50
disease	expressed_in	disease	0.50
Hippocampus	expressed_in	entity	0.50
ALZHEIMER'S	expressed_in	concept	0.50
HYPOTHALAMUS	expressed_in	concept	0.50
PSD-95	regulates	protein	0.50
Hippocampus	associated_with	entity	0.50
STRIATUM	associated_with	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMYGDALA

Understanding Entity Pages

Wiki Pages (21)

Amygdala

Alpha-Synuclein Pathology

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

GRIA3 Gene

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

williams-syndrome

CNTN5 — Contactin 5

Synucleinopathy Mechanism

Tau Spreading Mechanism

Blood-Brain Barrier Dysfunction in Neurodegeneration

ncam2

cerebral-cortical-vasal-neurons

CNTN6 — Contactin 6

CNTN4 — Contactin 4

Spinal Cord Dorsal Horn Neurons

Tau Strain Diversity and Conformational Templating in Tauopathies

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

Paraventricular Hypothalamic Nucleus (PVN) Neurons