| Gene Symbol | ALKBH5 |
| Aliases | AlkB Homolog 5 |
| Function | ALKBH5 (AlkB Homolog 5) is a 259-amino acid nuclear protein that functions as an N6-methyladenosine (m6A) demethylase. |
| Subcellular Localization | </strong> Nucleus</div>
<div class="infobox-row"><strong>Protein Family:</stro |
| Molecular Weight | 29.4 kDa |
| Amino Acids | 259 aa |
| Pathways | Spermatogenesis |
| GeneCards | ALKBH5 |
| Human Protein Atlas | ALKBH5 |
| m6A Demethylation | ALKBH5 removes m6A modifications from mRNA, regulating RNA stability, splicing, and translation |
| Synaptic Plasticity | ALKBH5 activity regulates synaptic protein synthesis and affects learning and memory formation |
| Neuronal Development | m6A demethylation by ALKBH5 regulates the expression of neurodevelopmental genes |
| Stress Response | ALKBH5 is recruited to stress granules under cellular stress, where it demethylates mRNAs involved in stress response |
| Small Molecule Modulators | Selective ALKBH5 inhibitors are being developed for cancer and neurological applications |
| m6A Homeostasis Restoration | Modulating ALKBH5 activity could restore normal m6A levels in disease states |
| Associated Diseases | Fertility, Male Infertility, Parkinson, Parkinson'S Disease, neurodegeneration |
| Known Drugs/Compounds | N6-Methyladenosine |
| Interactions | RNA, AND, JUN, APOPTOSIS, P53, TP53 |
| KG Connections | 73 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |