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disease 1,073 words KG: C9orf72
Contents

Amyotrophic Lateral Sclerosis (ALS)

Disease Info
Associated GenesAMYOTROPHIC LATERAL SCLEROSIS
KG Connections88 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

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Knowledge Graph

Agent Input

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🌐 Cross-references

OMIMMeSHWikipedia

Related Hypotheses (139)

HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57CX43 hemichannel engineering enables size-selective mitochon
Score: 0.57Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.57Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.55Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54Temporal Decoupling via Circadian Clock Reset
Score: 0.54Lysosomal Membrane Repair Enhancement
Score: 0.54Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54Blood-Brain Barrier SPM Shuttle System
Score: 0.53Cryptic Exon Silencing Restoration
Score: 0.53Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
Score: 0.47RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36
← Prevpg 7/7

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archivedMicroglial subtypes in neurodegeneration — friend vs foe
neuroscience · archived

Related Experiments (22)

s:** - Single-cell RNA-seq to measure editing efficiency acr
falsification · proposed · Score: 0.40Metabolic Pathway-Targeted Therapy in ALS
clinical · proposed · Score: 0.40ALS Progression Rate Heterogeneity — mechanism and biomarker
clinical · proposed · Score: 0.40ALS Regional Onset and Spread: Network-Level Staging Model
clinical · proposed · Score: 0.40Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

C9orf72 regulates MMP9
C9orf72 causes Frontotemporal dementia
C9orf72 causes lysosomal dysfunction
C9orf72 regulates TDP-43
CEREBELLUM associated_with C9orf72
C9orf72 interacts_with WDR41
C9orf72 involved_in Autoimmune Response
C9orf72 expressed_in presynaptic terminals
C9orf72 regulates dendritic arborization
C9orf72 expressed_in cerebellum

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