| Gene Symbol | BACH1 |
| Full Name | BTB Domain and CNC Homolog 1 |
| Chromosome | 21q21.3 |
| Function | encodes a transcriptional repressor that competes with NRF2 for binding to antioxidant response elements (AREs) in the promoters of cytoprotective genes. |
| Primary Expression | Ubiquitous, high in brain, liver, spleen |
| Pathways | Akt, Apoptosis, Autophagy, Chaperone, Complement |
| UniProt ID | O14867 |
| NCBI Gene ID | 571 |
| Ensembl ID | ENSG00000156273 |
| OMIM | 602751 |
| GeneCards | BACH1 |
| Human Protein Atlas | BACH1 |
| Represses HMOX1 | The HMOX1 promoter contains multiple AREs that are occupied by BACH1-Maf heterodimers in the absence of stress |
| Regulates iron metabolism | Controls ferritin heavy chain (FTH1) and ferroportin (SLC40A1) expression |
| Interactions | AKT, ANTIOXIDANT GENES, APOPTOSIS, ASTROCYTE, CANCER, CGAS |
| KG Connections | 157 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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