gene 725 words KG: FYN 2026-03-24
kind:genesection:genesstate:published
Contents

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

🧬 Gene Info
Gene SymbolFYN
Full NameFYN Proto-Oncogene, Src Family Tyrosine Kinase
AliasesFyn Tyrosine Kinase
Chromosome6q21.
Protein TypeReceptor
Functionencodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Primary ExpressionT-cells, NK cells, and other immune cells
Molecular Weight~60 kDa
Amino Acids537 aa
PathwaysAkt, Apoptosis, Dendritic Spine, Endocytosis, Pi3K
UniProt IDP39687
NCBI Gene ID2534
Ensembl IDENSG00000110881
OMIM137025
GeneCardsFYN
Human Protein AtlasFYN
Associated DiseasesALS, Aging, Alzheimer, Alzheimer's disease, Autism
InteractionsSRC, KEAP1, CUL3, NRF2, BACH1, LCK
KG Connections426 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (3)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (5)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: causes
Alzheimer Indonesia
institution · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
ADRB2 Gene
gene · KG edge: interacts_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target

Knowledge Graph (12 edges)

FYN interacts_with RELN
FYN interacts_with LCK
FYN involved_in NEURONAL MIGRATION
FYN associated_with SRC
FYN associated_with CAMK2A
FYN associated_with SNCA
FYN associated_with SLC6A3
FYN associated_with UBC
FYN associated_with HOMER1
FYN associated_with COMT