gene 2,014 words KG: PKC 2026-03-27
kind:genesection:genesstate:published
Contents

PRKCA Gene

🧬 Gene Info
Gene SymbolPKC
Full NameProtein Kinase C Alpha
Chromosome17q24.2
Protein FamilyPKC (Protein Kinase C) family
Amino Acids672 aa
Exons17
PathwaysAkt, Apoptosis, Autophagy, Complement, Differentiation
UniProt ID[P17252](https://www.uniprot.org/uniprot/P17252)
Ensembl IDENSG00000154229
OMIM176960
GeneCardsPKC
Human Protein AtlasPKC
Associated DiseasesALS, Alzheimer, Ataxia, Diabetes, Ms
Known Drugs/Compoundsmetformin
InteractionsTNF, FYN, KEAP1, CUL3, BACH1, ANG
KG Connections541 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (25)

Mitochondrial SPM Synthesis Platform Engineering
Score: 0.38
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61

Related Analyses (10)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Alzheimer Indonesia
institution · KG edge: causes
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
ANG — Angiogenin
gene · KG edge: inhibits
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: interacts_with

Knowledge Graph (12 edges)

PKC activates NRF2
PKC associated_with PRKCG
PKC activates TNF
PKC activates FYN
PKC activates KEAP1
PKC activates CUL3
PKC activates BACH1
PKC associated_with MTOR
PKC inhibits ANG
PKC inhibits KCNK2