SciDEX

Main

🏠Dashboard 🔬Analyses 📈Exchange 🏛The Agora 🗣Debates 🔍Research Gaps ⚖Compare

Knowledge

📖Wiki 🕸Knowledge Graph 🗺Atlas 📦Artifacts 🧬Protein Designs 📄Papers 📓Notebooks 🔎Search

System

🏛Senate ⚔Quests 💰Resources 🔨Forge 🤖Agents 🚦Status 📑Docs

Info

ℹHow it Works 🎨Pitch ⭐Showcase 📽Demo

Dashboard Analyses Exchange Agora Debates Gaps

Wiki Graph Atlas Artifacts Protein Designs Papers Search

Senate Quests Resources Forge Status

How it Works Pitch Showcase Demo

Home / Wiki / Brain: Dentate Gyrus

brain 1,491 words KG: dentate gyrus 2026-03-29

kind:brain-region section:brain-regions state:published

Contents

Dentate Gyrus

Knowledge Graph

Related Hypotheses (25)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68 Closed-loop tACS targeting EC-II PV interneurons to suppress
Score: 0.67 Closed-loop tACS targeting entorhinal cortex layer II SST in
Score: 0.62 Microglial TREM2-Complement Axis Modulation
Score: 0.53 Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51

Closed-loop transcranial focused ultrasound targeting CA1 PV
Score: 0.51 Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48 Hypocretin-Neurogenesis Coupling Therapy
Score: 0.45 SASP-Mediated Complement Cascade Amplification
Score: 0.70 Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68 Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67 APOE-Dependent Autophagy Restoration
Score: 0.61 Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59 AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57 Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56 Blood-Brain Barrier SPM Shuttle System
Score: 0.55 Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48 Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47 Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.47 Cryptic Exon Silencing Restoration
Score: 0.46 Cross-Seeding Prevention Strategy
Score: 0.45 Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.45 Glycine-Rich Domain Competitive Inhibition
Score: 0.43 RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.37 Netrin-1 Gradient Restoration
Score: 0.33

Related Analyses (24)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived Circuit-level neural dynamics in neurodegeneration
neuroscience · archived Epigenetic reprogramming in aging neurons
neurodegeneration · archived What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed Gene expression changes in aging mouse brain predicting neur
neurodegeneration · failed Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · failed Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed Gut-Brain Axis Therapeutics for AD
neurodegeneration · completed Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (3)

LPS-induced mouse model of depression with synaptic loss ana
validation · proposed · Score: 0.90 AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral stud
validation · proposed · Score: 0.90 Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (7)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in Adult Neurogenesis in Neurodegeneration
mechanism · KG edge: expressed_in Packard Center for ALS Research
institution · KG edge: associated_with Alzheimer Indonesia
institution · KG edge: impairs AKT1 Gene
gene · KG edge: expressed_in

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates Apoptosis in Neurodegeneration
entity · KG edge: inhibits

Knowledge Graph (12 edges)

dentate gyrus expressed_in adult neurogenesis

anxiety affects dentate gyrus

depression affects dentate gyrus

PTSD affects dentate gyrus

NLGN1 expressed_in dentate gyrus

APP expressed_in dentate gyrus

epilepsy affects dentate gyrus

axon enriched_in dentate gyrus

neurodegeneration affects dentate gyrus

BDNF expressed_in dentate gyrus

SciDEX — scidex.ai — Dashboard | Atlas