| Gene Symbol | LAMTOR1 |
| Full Name | Late Endosomal/Lysosomal Adaptor 1 |
| Aliases | Page for LAMTOR1 |
| Function | LAMTOR1 (Late Endosomal/Lysosomal Adaptor 1) is a key component of the ragulator complex that regulates mTORC1 signaling. |
| Pathways | MTOR, mTOR, MAPK, mtor |
| Ensembl ID | ENSG00000149357 |
| GeneCards | LAMTOR1 |
| Human Protein Atlas | LAMTOR1 |
| mTORC1 Activation | LAMTOR1 is essential for mTORC1 activation by amino acids. The ragulator complex localizes to lysosomes where it activates mTORC1 in response to nutrient availability. |
| Rag GTPase Regulation | LAMTOR1 forms a complex with LAMTOR2 and LAMTOR3, acting as a guanine nucleotide exchange factor (GEF) for Rag GTPases. |
| Lysosomal Trafficking | The LAMTOR complex regulates endosomal and lysosomal trafficking, influencing autophagy and nutrient sensing. |
| ERK Pathway Modulation | LAMTOR1 also modulates ERK/MAPKmechanisms/mapk-signaling-neurodegeneration) signaling, connecting it to cell growth and differentiation. |
| Autophagy Impairment | LAMTOR1 is crucial for autophagy, and its dysfunction may lead to accumulation of amyloid and tau aggregates. |
| Lysosomal Function | The protein's role in lysosomal signaling affects cellular waste clearance, which is impaired in AD. |
| Autophagy-Lysosome Pathway | LAMTOR1 dysfunction contributes to impaired autophagy and α-synuclein clearance. |
| Associated Diseases | neurodegeneration |
| Interactions | AND, AUTOPHAGY, MAPK, MTOR, MTORC1 |
| SciDEX Hypotheses | Mitochondrial-Lysosomal Coupling Enhancer |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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