| Gene Symbol | SYNGAP1 |
| Full Name | Synaptic Ras GTPase Activating Protein 1 |
| Chromosome | 6p21.3 |
| Function | is a major postsynaptic density (PSD) protein that regulates Ras signaling and controls AMPA receptor trafficking, making it essential for synaptic plasticity, learning, and memory. |
| Primary Expression | Brain (cortex, hippocampus), postsynaptic densities |
| Molecular Weight | 150 kDa |
| Amino Acids | 1343 aa |
| UniProt ID | [Q9ULB0](https://www.uniprot.org/uniprot/Q9ULB0) |
| Ensembl ID | ENSG00000197283 |
| OMIM | 603384 |
| GeneCards | SYNGAP1 |
| Human Protein Atlas | SYNGAP1 |
| N-terminal domain | Contains a C2 domain (Ca²⁺/lipid-binding) |
| PDZ-binding motif | Mediates interaction with PSD-95 and other scaffolding proteins |
| SH3 domain | Protein-protein interactions |
| Associated Diseases | neurodegeneration |
| Interactions | ERK, RAS, STXBP1 |
| SciDEX Hypotheses | Interneuron SYNGAP1 Deficiency Disrupts Cortical C |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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