protein 1,100 words KG: STXBP1 2026-03-24
kind:proteinsection:proteinsstate:published
Contents

Munc18-1 Protein

🔬 Protein Info
Gene SymbolSTXBP1
Full NameMunc18-1
Protein TypeProtein
Functionis a neuronal protein essential for synaptic vesicle release and neurotransmitter secretion.
Primary Expressionnon-neuronal tissues, important for immune function
Molecular Weight66 kDa
Amino Acids594 aa
UniProt IDSearch UniProt
GeneCardsSTXBP1
Human Protein AtlasSTXBP1
Associated DiseasesALS, neurodegeneration
InteractionsSYNGAP1, DNAJC5, ERK, AND, SNAP-25, HSC70
KG Connections36 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Proteins
index · KG edge: interacts_with
Ras-MAPK Signaling Pathway in Neurodegeneration
mechanism · KG edge: inhibits
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: interacts_with

Knowledge Graph (12 edges)

STXBP1 inhibits SYNGAP1
STXBP1 therapeutic_target SCN1A
STXBP1 interacts_with DNAJC5
STXBP1 interacts_with Synaptic Vesicle
STXBP1 associated_with neurodegeneration
STXBP1 associated_with WWOX
STXBP1 inhibits ERK
STXBP1 therapeutic_target Aging
STXBP1 therapeutic_target Als
STXBP1 therapeutic_target Ms