gene 824 words KG: DYRK1A 2026-03-24
kind:genesection:genesstate:published
Contents

DYRK1A Gene - Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A

🧬 Gene Info
Gene SymbolDYRK1A
Full NameDual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A
AliasesDYRK1A gene page, Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A
Chromosome21q22.13
Protein TypeSerine/Threonine Kinase
FunctionThe DYRK1A gene encodes Dual Specificity Tyrosine-Phosphorylation Regulated Kinase 1A, a member of the dual-specificity tyrosine-regulated kinase (DYRK) family.
Primary Expressionindividuals with trisomy 21 (Down syndrome)
Molecular Weight85 kDa
Amino Acids754 aa
PathwaysApoptosis, Differentiation
UniProt IDQ13627
NCBI Gene ID1785
Ensembl IDENSG00000157540
OMIM600855
GeneCardsDYRK1A
Human Protein AtlasDYRK1A
Associated DiseasesALS, Alzheimer, Cancer, Epilepsy, Neurodegeneration
InteractionsNRF2, OPTN, FGFR1, PTEN, PIK3CA, NRAS
KG Connections183 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (8)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.51
Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50

Related Analyses (9)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: inhibits
DIABLO
gene · KG edge: regulates
BRAF — B-Raf Proto-Oncogene, Serine/Threonine Kinase
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DYRK1A regulates SMAC
DYRK1A regulates AIF
DYRK1A regulates P38
DYRK1A regulates MDM2
DYRK1A regulates EGF
DYRK1A regulates DIABLO
DYRK1A regulates MYC
DYRK1A activates NRF2
DYRK1A activates OPTN
DYRK1A associated_with MTOR