gene 1,529 words KG: PIK3C3 2026-03-28
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (VPS34)

🧬 Gene Info
Gene SymbolPIK3C3
Full NamePhosphatidylinositol 3-Kinase Catalytic Subunit Type 3
AliasesVPS34, PI3K-III
Chromosome18q12.3
Protein FamilyClass III Phosphoinositide 3-kinase (PI3K3C)
Subcellular LocalizationCytosol, endosomal membrane, phagophore
Molecular Weight100 kDa
Amino Acids887 aa
Exons32
PathwaysPI3K
UniProt IDQ8N3F7
NCBI Gene ID5289
Ensembl IDENSG00000055070
OMIM602609
GeneCardsPIK3C3
Human Protein AtlasPIK3C3
Associated DiseasesAD, ADH, ALS, AMI, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsEGFR, PPARG, HSPA5, MAVS, FIP200, AMBRA1
KG Connections1124 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
APOE-Dependent Autophagy Restoration
Score: 0.61
Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.56

Related Analyses (10)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived

Related Experiments (19)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
AMBRA1 Gene
gene · KG edge: associated_with
AKT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PIK3C3 regulates CELL_POLARITY
PIK3C3 regulates EGFR
PIK3C3 regulates PPARG
PIK3C3 regulates LAMP1
PIK3C3 regulates RUBCN
PIK3C3 regulates RPS6
PIK3C3 interacts_with EGFR
PIK3C3 interacts_with PPARG
PIK3C3 interacts_with HSPA5
PIK3C3 interacts_with MAVS