gene 3,179 words KG: PRDX2 2026-03-27
kind:genesection:genestopic:antioxidanttopic:peroxiredoxintopic:oxidative-stresstopic:parkinsonstopic:alzheimerstopic:neuroprotectionstate:published
Contents

PRDX2 — Peroxiredoxin 2

🧬 Gene Info
Gene SymbolPRDX2
Full NamePeroxiredoxin 2
Chromosome19p13.13
Protein TypeEnzyme
Functionis a critical antioxidant enzyme in the neurobiology of neurodegenerative diseases.
Primary ExpressionErythrocytes, Brain, Liver, Kidney, Heart
Molecular Weight22 kDa
Amino Acids198 aa
UniProt IDP32189
NCBI Gene ID7003
Ensembl IDENSG00000167612
OMIM607386
GeneCardsPRDX2
Human Protein AtlasPRDX2
Associated DiseasesParkinson's disease, Alzheimer's disease
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Extracellular Matrix Stiffness Modulation
Score: 0.43
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.41

Related Analyses (3)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (8)

Packard Center for ALS Research
institution · KG edge: expressed_in
TXN — Thioredoxin
gene · KG edge: associated_with
PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subuni
gene · KG edge: associated_with
GRB2 — Growth Factor Receptor Bound Protein 2
gene · KG edge: associated_with
AP2B1 — Adaptor Related Protein Complex 2 Subunit Beta
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PRDX2 provides_data_for ds-83b31ef18d49
PRDX2 associated_with PIK3C3
PRDX2 expressed_in Als
PRDX2 expressed_in Ms
PRDX2 upregulates TREM2
PRDX2 data_in benchmark_ot_ad_answer_key:PRDX2
ds-83b31ef18d49 data_in PRDX2
NR3C1 associated_with PRDX2
TXN associated_with PRDX2
AP2B1 associated_with PRDX2